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Figure 5 | BMC Cancer

Figure 5

From: Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma

Figure 5

Tbx3 represses induced PTEN promoter activity. HeLa and HEK cell lines were transfected with the CP-PTEN reporter plasmid. Luciferase activity of CP-PTEN was measured in response to over expressed USF with or without Tbx3. USF is capable of inducing the transcriptional activity of CP-PTEN by 1.5-fold and Tbx3 is capable of repressing the induced transcription activity by 3-fold (p<0.05). pGL3 control and pGL3 Basic plasmids were transfected into both of the cell lines as positive and negative controls, respectively. The sign “*” denotes for statistically significant difference in PTEN promoter activity with respect to the basal activity (100%).

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