Figure 3
From: Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma
Schematic diagram of PTEN promoter. (A) Core promoter of PTEN localized between −1345 to −745 is shown. The beginning of exon 1 is designated as (0) and the start codon “ATG” within the first exon is indicated. A 1030 bp long leader sequence (LS) is found between the beginning of the first exon and the ATG site. The gray area between −958 and −821 is the minimal promoter of PTEN. Binding sites for the main transcription factors within the core promoter region are shown. (B) The EP-PTEN, CP-PTEN and Δ mut. CP-PTEN promoter constructs used in this study are shown. All promoter regions were cloned into the luciferase expressing plasmid pGL3 (Luc).