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Table 5 Multivariate logistic regression analysis of predictive factors of treatments administered

From: Population-based study of breast cancer in older women: prognostic factors of relative survival and predictors of treatment

Variables

OR

95% CI

p value

Predictive factors for surgery alone * (N=537)

Age

  

0.06

75-79

1

  

80-84

1.28

0.57-2.88

 

≥85

2.52

1.15-5.54

 

N stage

  

0.05

N0

1

  

N+

0.36

0.13-1.01

 

Hormone receptors

  

0.008

Negative

1

  

Positive

0.29

0.12-0.72

 

Period

  

0.008

1998-2003

1

  

2004-2008

0.40

0.20-0.78

 

Histoprognostic SBR grade

  

0.25

1+2

1

  

3

1.59

0.72-3.49

 

Place of residence

  

0.16

Rural

1

  

Urban

1.84

0.78-4.33

 

Predictive factors for hormone therapy alone (N=452)

Age

  

<0.001

75-79

1

  

80-84

2.07

0.80-5.35

 

≥85

16.22

6.74-39.03

 

T stage

   

T0+T1

1

 

0.89

T2

1.21

0.53-2.74

 

T3+T4

1.22

0.42-3.52

 

N stage

  

0.52

N0

1

  

N+

1.32

0.57-3.07

 

M stage

  

0.02

M0

1

  

M1

3.67

1.25-10.74

 

Comorbidities

  

<0.001

No

1

  

Yes

7.59

2.45-23.56

 

Histoprognostic SBR grade

  

0.22

1+2

1

  

3

0.55

0.21-1.43

 

Period

  

0.23

1998-2003

1

  

2004-2008

1.56

0.75-3.24

 

Hormone receptors

  

0.07

Negative

1

  

Positive

4.73

0.90-24.94

 

Diagnosis circumstances

  

0.55

Clinic

1

  

Individual screening

0.72

0.24-2.13

 

Place of residence

  

1

Rural

1

  

Urban

1

0.47-2.12

 

Predictive factors for BCS plus adjuvant therapy † (N=381)

Age

  

<0.001

75-79

1

  

80-84

0.53

0.30-0.95

 

≥85

0.21

0.09-0.50

 

T stage

  

<0.001

T0 +T1

1

  

T2

0.17

0.09-0.31

 

T3+T4

0.13

0.05-0.30

 

N stage

  

0.23

N0

1

  

N+

0.64

0.31-1.33

 

Comorbidities

  

0.11

No

1

  

Yes

0.62

0.34-1.12

 

Diagnosis circumstances

  

0.10

Clinic

1

  

Individual screening

1.71

0.90-3.24

 

Histoprognostic SBR grade

  

0.30

1+2

1

  

3

0.7

0.36-1.37

 

Matrimonial status

  

0.40

Single‡

1

  

Not single

1.26

0.73-2.17

 

Hormone receptors

  

0.78

Negative

1

  

Positive

1.14

0.46-2.83

 

Predictive factors for mastectomy plus adjuvant therapy (N=381)

T stage

  

<0.001

T0+T1

1

  

T2

5.57

3.09-10.03

 

T3+T4

3.60

1.78-7.29

 

N stage

  

0.61

N0

1

  

N+

0.86

0.49-1.53

 

M stage

  

0.07

M0

1

  

M1

0.47

0.21-1.08

 

Histoprognostic SBR grade

  

0.005

1+2

1

  

3

2.18

1.26-3.76

 

Matrimonial status

  

0.19

Single‡

1

  

Not single

0.72

0.44-1.18

 

Place of residence

  

0.22

Rural

1

  

Urban

0.73

0.44-1.20

 

Age x diagnosis circumstances §

  

<0.001

75-79 x clinical diagnosis

1

  

80-84 x clinical diagnosis

1.63

0.91-2.93

 

≥85 x clinical diagnosis

0.26

0.13-0.52

 

75-79 x individual screening

0.45

0.17-1.18

 

80-84 x individual screening

0.33

0.09-1.18

 

≥85 x individual screening

1.25

0.24-6.38

 
  1. Abbreviations: OR = Odds Ratios; CI = confidence interval, N = number of patients.
  2. *Predictive factors for surgery alone without the variable M stage because no patient with stage M1 had surgery alone.
  3. †Predictive factors for BCS plus adjuvant therapy without the variable M stage because only 4 patients with stage M1 received BCS plus adjuvant therapy.
  4. ‡patient single, divorced or widowed.
  5. §Interaction age and diagnosis circumstances.
  6. NB: Multivariate logistic regression analyses were adjusted for age, TNM stage, period, diagnosis circumstances, comorbidities, histoprognostic SBR grade, tumour type, hormone receptors, matrimonial status, and place of residence.
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BMC Cancer

ISSN: 1471-2407

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