Table 1 Selected inflammatory genes and their association with biliary stones and cancer in the Shanghai population
Evaluated SNPs | |||||
|---|---|---|---|---|---|
Gene symbol (name) | Gene function | Chromosome location | Examined in the current study | Previously reported variants1 | High linkage disequilibrium |
IL8 (interleukin 8) | Neutrophil chemotaxis | 4q12-q13 | rs12506479, rs10805066 rs2227543, rs7657356 | rs4073, rs2227307, rs2227306 | rs2227307, rs4073, rs2227543 and rs2227306 (r2>0.8) |
NFKBIL (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) | Encodes divergent member of I-kappa-B family proteins | 6p21.3 | rs2230365, rs2239707, rs2857605, rs928815, rs13215091 | ||
RNASEL (ribonuclease L) | Encodes an interferon-inducible ribonuclease | 1q25 | rs11807829, rs474939, rs533259, rs682585, rs627839, rs627928, rs635261, rs672527, rs579006 | rs11072, rs486907 | rs11807829 and rs11072 (r2=0.98), rs635261 and rs627839 (r2=0.8), rs579006 with rs486907 (r2=0.95) |
TNF (tumor necrosis factor) | Inflammatory cytokine that promotes hyperlipidemia by increasing hepatic triglyceride production and decreasing clearance | 6p21.3 | rs2857708, rs769177, rs769178 | rs1800750, rs1800629, rs361525, rs673, rs1799724, rs1800630, rs1800610, rs1799964 | rs769178 and rs1799724 (r2=0.95) |
VEGFA (vascular endothelial growth factor A) | Vascular permeability, angiogenesis, vasculogenesis, cell growth, cell migration, apoptosis | 6p12 | rs25648, rs3025000, rs3025033, rs3025035, rs833052, rs866236, rs9367173, rs9394963, rs998584, rs10434, rs6905288, rs6899540, rs4714696, rs833070 | rs3025039 | (rs3025033 and rs3025039 (r2=0.93) |