Table 2 Odds ratios and heterogeneity results in the meta-analysis of the association between MTHFR 677C>T polymorphism and cervical cancer
From: The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis
Contrast model | Studies (participants) | Fixed effects model | Random effects model | PH‡ | I2 (%) | ||
|---|---|---|---|---|---|---|---|
OR[95%CI]* | POR | OR[95%CI] | POR | ||||
Total studies# | |||||||
TT versus CC | 11(4,576) | 1.05(0.85-1.30) | 0.644 | 1.06(0.72-1.56) | 0.773 | 0.008 | 58.2% |
CT versus CC | 11(4,576) | 0.81(0.70-0.92) | 0.002 | 0.86(0.67-1.11) | 0.247 | 0.002 | 63.5% |
TT + CT versus CC | 11(4,576) | 0.83(0.73-0.95) | 0.005 | 0.90(0.68-1.20) | 0.481 | <0.001 | 73.3% |
TT versus CT + CC | 11(4,576) | 1.14(0.94-1.38) | 0.171 | 1.14(0.84-1.54) | 0.412 | 0.052 | 45.1% |
Caucasians | |||||||
T versus C | 6(2,769) | 0.74(0.65-0.84) | <0.001 | 0.74(0.54-1.01) | 0.056 | 0.004 | 71.0% |
TT versus CC | 6(2,769) | 0.63(0.45-0.88) | 0.007 | 0.64(0.45-0.89) | 0.009 | 0.794 | 0.0% |
CT versus CC | 6(2,769) | 0.69(0.58-0.82) | <0.001 | 0.74(0.50-1.09) | 0.122 | 0.003 | 71.7% |
TT + CT versus CC | 6(2,769) | 0.68(0.58-0.80) | <0.001 | 0.71(0.49-1.04) | 0.082 | 0.003 | 72.8% |
TT versus CT + CC | 6(2,769) | 0.73(0.52-1.01) | 0.056 | 0.73(0.53-1.02) | 0.067 | 0.871 | 0.0% |
East Asians | |||||||
T versus C | 4(1,648) | 1.24(1.07-1.44) | 0.004 | 1.28(1.02-1.62) | 0.034 | 0.092 | 53.5% |
TT versus CC | 4(1,648) | 1.56(1.17-2.08) | 0.003 | 1.66(1.05-2.62) | 0.029 | 0.097 | 52.6% |
CT versus CC | 4(1,648) | 1.08(0.85-1.37) | 0.514 | 1.08(0.85-1.37) | 0.518 | 0.754 | 0.0% |
TT + CT versus CC | 4(1,648) | 1.20(0.96-1.50) | 0.102 | 1.21(0.95-1.54) | 0.120 | 0.340 | 10.6% |
TT versus CT + CC | 4(1,648) | 1.51(1.17-1.94) | 0.001 | 1.55(1.09-2.22) | 0.016 | 0.157 | 42.4% |
Europeans | |||||||
T versus C | 3(1,632) | 0.77(0.66-0.89) | 0.001 | 0.77(0.66-0.89) | 0.001 | 0.828 | 0.0% |
TT versus CC | 3(1,632) | 0.65(0.45-0.93) | 0.020 | 0.65(0.45-0.93) | 0.020 | 0.991 | 0.0% |
CT versus CC | 3(1,632) | 0.71(0.58-0.88) | 0.002 | 0.71(0.58-0.88) | 0.002 | 0.552 | 0.0% |
TT + CT versus CC | 3(1,632) | 0.70(0.58-0.86) | <0.001 | 0.70(0.58-0.86) | <0.001 | 0.658 | 0.0% |
TT versus CT + CC | 3(1,632) | 0.75(0.53-1.07) | 0.113 | 0.75(0.53-1.07) | 0.113 | 0.922 | 0.0% |
Indians§ | |||||||
TT versus CC | 3(1,137) | 0.51(0.20-1.30) | 0.157 | 0.54(0.19-1.59) | 0.260 | 0.321 | 12.0% |
TT versus CT + CC | 3(1,137) | 0.57(0.22-1.46) | 0.239 | 0.60(0.23-1.59) | 0.305 | 0.471 | 0.0% |