Figure 5
Survival time of the ES-2 peritoneal metastasis mouse model after treatment with CPT-11 or IHL-305. ES-2 cells (2 x 105 cells) were inoculated into the peritoneal cavity of mice on day 1. (A) Saline as the vehicle control (●), CPT-11 (45 mg/kg/day: ▲) or IHL-305 (45 mg/kg/day: ■) was administered on days 4, 8, and 12, and the survival time was analyzed (n=10, each group). (B) Saline was administered as the vehicle control (●). IHL-305 (45 mg/kg) was administered on days 4, 8 and 12 (schedule A, ▲), days 8, 12 and 16 (schedule B, ■) or days 12, 16 and 20 (schedule C, ♦), and the survival time was analyzed (n=5, each group).