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Figure 7 | BMC Cancer

Figure 7

From: Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

Figure 7

HA-induced erbB receptor activation in TamR cells promotes cell migration. (A) Treatment of TamR cells with HA is accompanied by upregulation of activated EGFR, erbB2 and ERK1/2; this was not apparent in cells in which CD44 expression was suppressed using siRNA. (B) To investigate the contribution of erbB signalling to HA-mediated cell migration, TamR wounding assays were performed in the presence of HA and in the presence or absence of the erbB2 inhibitor (trastuzumab) or the EGFR inhibitor (gefitinib). Inhibition of either erbB2 or the EGFR resulted in partial inhibition of HA-mediated TamR migration. *p=0.05 versus control.

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