Deletion of the TNFAIP3/A20gene detected by FICTION analysis in classical Hodgkin lymphoma

BMC Cancer

Table 2 FICTION analysis

Case #	Mutation	Control CD30-)	HR-S (CD30+)	HR-S/ Control	Predicted allele*
1	W	1.02	0.90	0.88	2
2	W	0.98	0.63	0.64	2
3	1487C>A (T474N)	0.99	0.71	0.72	2
4	W	1.11	0.80	0.72	2
5	W	1.11	0.54	0.49	1
6	W	1.06	0.14	0.13	0
7	W	0.94	0.65	0.69	2
8	W	0.96	0.45	0.47	1
9	W	1.01	0.64	0.63	2
10	W	0.97	0.77	0.79	2
11	W	1.02	0.81	0.79	2
12	ND	1.03	0.22	0.21	0
13	ND	0.99	0.93	0.94	2
14	ND	1.12	0.78	0.70	2
15	ND	1.04	0.83	0.80	2
16	ND	1.05	0.42	0.40	1
17	ND	1.19	1.07	0.90	2
18	ND	1.00	0.67	0.67	2
19	ND	1.17	0.50	0.43	1
20	ND	0.99	0.90	0.91	2
21	ND	0.95	0.21	0.22	0
22	ND	0.97	0.68	0.70	2
23	ND	0.93	0.71	0.76	2
24	ND	0.99	0.70	0.71	2
25	ND	1.00	0.82	0.82	2
26	ND	1.00	0.14	0.14	0
27	ND	1.02	0.32	0.31	1
28	ND	0.99	0.50	0.51	1
29	ND	0.99	0.41	0.41	1
30	ND	0.97	0.76	0.78	2
31	W	1.03	0.45	0.44	1
32	W	1.01	0.88	0.86	2
33	W	0.97	0.52	0.53	1
34	W	0.99	0.52	0.52	1
35	W	1.00	0.93	0.93	2
36	W	0.90	0.63	0.71	2
37	W	0.98	0.43	0.44	1
38	1777G>A (V571I)	1.04	0.72	0.69	2
39	W	1.06	1.00	0.94	2
40	1156A>G (R364G)	0.86	0.15	0.17	ND
41	W	0.91	0.19	0.21	0
42	W	0.89	0.31	0.35	ND
43	W	1.00	0.36	0.36	1
44	W	1.01	0.52	0.51	1
45	W	0.84	0.68	0.81	ND
46	569G>A (STOP)	0.99	0.69	0.70	2
47	W	1.00	0.45	0.45	1
	3/25 (12%)	Mean 1.01	Mean 0.61	Mean 0.60

* 0: homozygous, 5 cases; 1: heterozygous, 14 cases; 2: non deleted, 25 cases.
W, wild type; ND, not determined.
Cases #1-5 and #31-47 had been sequenced and reported elsewhere. Cases #6-11 were sequenced in this study. Cases #12-30 were not sequenced because of limited or poor quality DNA.

ISSN: 1471-2407