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Figure 6 | BMC Cancer

Figure 6

From: Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay

Figure 6

Cell proliferation and apoptosis in adenocarcinomas of the 5-FU treated KAD rats. (A) The PCNA labeling index was significantly lower in the 5-FU treated KAD rats (50 mg/kg) than that in the control KAD rats, indicating significant decrease in cell proliferation in the adenocarcinomas. **: p < 0.001. (B) The cleaved caspase-3 positive rate was significantly higher in the 5-FU treated KAD rats (50 mg/kg) than that in the control KAD rats, indicating significant increase in apoptosis in the adenocarcinomas. *: p < 0.02.

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