Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study

Josef Thaler; Meinolf Karthaus; Laurent Mineur; Richard Greil; Henry Letocha; Ralf Hofheinz; Eva Fernebro; Erick Gamelin; Ana Baños; Claus-Henning Köhne

doi:10.1186/1471-2407-12-438

Table 6 PRO EQ-5D and QLQ-C30 subscale scores at baseline and safety follow-up

From: Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study

	KRASPRO analysis set				PRO analysis set
	WT KRAS(n = 76)^a		MT KRAS(n = 54)^a		Overall (n = 137)^a
	Baseline	Safety follow-up	Baseline	Safety follow-up	Baseline	Safety follow-up
Mean (SD) EQ-5D subscale scores ^b
Mobility	1.13 (0.34)	1.17 (0.38)	1.13 (0.34)	1.12 (0.42)	1.12 (0.33)	1.16 (0.41)
Self care	1.05 (0.23)	1.14 (0.35)	1.13 (0.44)	1.15 (0.51)	1.08 (0.32)	1.15 (0.43)
Usual activities	1.29 (0.56)	1.39 (0.60)	1.35 (0.59)	1.34 (0.65)	1.30 (0.56)	1.38 (0.62)
Pain/discomfort	1.45 (0.58)	1.53 (0.56)	1.53 (0.58)	1.46 (0.56)	1.46 (0.57)	1.51 (0.56)
Anxiety/depression	1.26 (0.50)	1.25 (0.44)	1.39 (0.49)	1.33 (0.48)	1.31 (0.49)	1.30 (0.46)
Mean (SD) QLQ-C30 functioning scores ^c
Physical	71.7 (20.1)	71.3 (20.5)^d	71.9 (19.6)	78.6 (10.5)^d	72.5 (19.8)	74.3 (18.2)^d
Role	26.1 (33.4)	30.0 (33.3)	32.1 (35.0)	28.8 (29.8)	27.4 (33.7)	30.3 (31.2)
Cognitive	10.2 (17.7)	13.3 (19.7)	13.6 (22.7)	14.1 (18.2)	11.0 (19.6)	14.4 (19.6)
Emotional	24.3 (23.1)	22.1 (20.0)	26.5 (22.9)	14.9 (19.0)	24.6 (22.6)	19.8 (20.5)
Social	25.8 (33.4)	25.7 (27.8)	23.5 (32.6)	16.7 (21.2)	23.6 (32.5)	22.4 (24.9)
Mean (SD) QLQ-C30 symptom scores ^e
Fatigue	29.0 (27.8)	31.9 (28.3)	35.4 (31.6)	31.3 (22.6)	31.4 (28.8)	32.3 (26.0)
Pain	19.1 (27.4)	22.9 (27.4)	25.3 (29.6)	19.3 (26.1)	21.2 (27.9)	21.6 (26.6)
Nausea/vomiting	3.3 (10.6)	7.6 (14.2)	8.6 (19.1)	10.6 (19.9)	5.3 (14.6)	8.6 (16.8)
Mean (SD) QLQ-C30 single-item scores ^e
Dyspnoea	17.1 (27.5)	21.0 (28.1)	23.5 (30.8)	21.2 (21.8)	19.2 (28.5)	21.3 (26.4)
Insomnia	29.8 (35.8)	23.8 (28.7)	28.4 (32.0)	23.2 (27.0)	29.4 (34.2)	25.0 (28.9)
Appetite loss	18.9 (31.0)	15.2 (30.6)	25.9 (35.3)	15.2 (27.8)	20.7 (32.4)	14.4 (28.4)
Constipation	13.3 (23.2)	4.8 (14.3)	14.2 (25.6)	12.1 (23.3)	14.0 (23.8)	9.7 (22.0)
Diarrhoea	20.7 (30.6)	12.4 (23.0)	19.1 (30.8)	22.2 (27.2)	19.5 (30.0)	18.1 (25.6)
Financial impact	8.1 (20.5)	7.6 (18.2)	6.8 (17.6)	11.5 (26.2)	7.2 (18.8)	9.4 (22.0)

^aActual ‘n’ number may differ according to subscale item and time point (data from fewer patients were available at safety follow-up vs. baseline); ^bHigher scores indicate a better level of functioning of a greater degree of symptomology depending on subscale; ^cA higher score indicates a better level of functioning/health; ^cA higher score indicates a better level of functioning/health; ^dData not available at safety follow-up, data reported at week 48 instead; ^eA higher score indicates a greater degree of symptomology.

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