Advertisement
Table 3 Kaplan-Meier analysis of integument-related toxicities
| Median (95% CI) | |||
|---|---|---|---|
| WT KRAS | MT KRAS | Overall | |
| (n = 86) | (n = 59) | (n = 154) | |
| Time to first integument toxicity, days [min, max] | |||
| Any grade | 8.0 (7,0, 10.0) | 10.0 (7.0, 13.0) | 8.0 (7.0, 11.0) |
| [0, 155] | [0, 125] | [0, 155] | |
| Grade ≥3 | NE (300.0, NE) | NE (175.0, NE) | 408.0 (300.0, NE) |
| [6, 528] | [0, 389] | [0, 528] | |
| Duration of integument toxicity, days [min, max] | |||
| Any grade | 452.0 (244.0, NE) | 321.0 (228.0, 371.0) | 334.0 (244.0, NE) |
| [14, 492] | [19, 445] | [14, 492] | |
| Grade ≥3 | 32.0 (17.0, 43.0) | 55.5 (25.0, 80.0) | 36.0 (25.0, 54.0) |
| [5, 322] | [5, 268] | [5, 322] | |
| Time to resolution, days [min, max] | |||
| Any grade | 103.0 (55.0, NE) | 71.0 (52.0, 86.0) | 71.0 (59.0, 162.0) |
| [0, 309] | [5, 162] | [0, 309] | |
| Grade ≥3 | 103.0 (68.0, NE) | 86.0 (86.0, 162.0) | 86.0 (68.0, 162.0) |
| [0, 124] | [12, 162] | [0, 162] | |
