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Table 3 Kaplan-Meier analysis of integument-related toxicities

From: Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study

  Median (95% CI)
WT KRAS MT KRAS Overall
(n = 86) (n = 59) (n = 154)
Time to first integument toxicity, days [min, max]
  Any grade 8.0 (7,0, 10.0) 10.0 (7.0, 13.0) 8.0 (7.0, 11.0)
[0, 155] [0, 125] [0, 155]
  Grade ≥3 NE (300.0, NE) NE (175.0, NE) 408.0 (300.0, NE)
  [6, 528] [0, 389] [0, 528]
Duration of integument toxicity, days [min, max]
  Any grade 452.0 (244.0, NE) 321.0 (228.0, 371.0) 334.0 (244.0, NE)
[14, 492] [19, 445] [14, 492]
  Grade ≥3 32.0 (17.0, 43.0) 55.5 (25.0, 80.0) 36.0 (25.0, 54.0)
  [5, 322] [5, 268] [5, 322]
Time to resolution, days [min, max]
  Any grade 103.0 (55.0, NE) 71.0 (52.0, 86.0) 71.0 (59.0, 162.0)
[0, 309] [5, 162] [0, 309]
  Grade ≥3 103.0 (68.0, NE) 86.0 (86.0, 162.0) 86.0 (68.0, 162.0)
  [0, 124] [12, 162] [0, 162]
  1. NE not estimable.