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Table 2 Most common integument-related toxicities (any grade; incidence ≥10% in the overall group)

From: Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study

  n(%)
WT KRAS(n = 86) MT KRAS(n = 59) Overall (n = 154)
Any grade Grade ≥3 Any grade Grade ≥3 Any grade Grade ≥3
Any integument-related AE 84 (98) 29 (34) 58 (98) 22 (37) 151 (98) 55 (36)
Rash 37 (43) 7 (8) 21 (26) 6 (10) 64 (42) 15 (10)
Dry skin 39 (45) 0 (0) 21 (36) 1 (2) 61 (40) 1 (1)
Acne 29 (34) 6 (7) 22 (37) 8 (14) 55 (36) 15 (10)
Alopecia 25 (29) 1 (1) 26 (44) 2 (3) 52 (34) 3 (2)
Paronychia 20 (23) 6 (7) 15 (25) 2 (3) 38 (25) 10 (6)
Conjunctivitis 23 (27) 1 (1) 8 (14) 1 (2) 33 (21) 3 (2)
Dermatitis acneiform 19 (22) 5 (6) 13 (22) 3 (5) 33 (21) 8 (5)
Skin fissures 20 (23) 3 (3) 10 (17) 1 (2) 32 (21) 4 (3)
Pruritus 21 (24) 1 (1) 8 (14) 0 (0) 30 (19) 1 (1)
PPE syndrome 12 (14) 1 (1) 13 (22) 2 (3) 25 (16) 3 (2)
Skin toxicity 14 (16) 4 (5) 4 (7) 1 (2) 18 (12) 5 (3)
Erythema 10 (12) 2 (2) 4 (7) 1 (2) 16 (10) 3 (2)
  1. AE adverse event; PPE palmar-plantar erythrodysaesthesia.