Table 2 Most common integument-related toxicities (any grade; incidence ≥10% in the overall group)
n(%) | ||||||
|---|---|---|---|---|---|---|
WT KRAS(n = 86) | MT KRAS(n = 59) | Overall (n = 154) | ||||
Any grade | Grade ≥3 | Any grade | Grade ≥3 | Any grade | Grade ≥3 | |
Any integument-related AE | 84 (98) | 29 (34) | 58 (98) | 22 (37) | 151 (98) | 55 (36) |
Rash | 37 (43) | 7 (8) | 21 (26) | 6 (10) | 64 (42) | 15 (10) |
Dry skin | 39 (45) | 0 (0) | 21 (36) | 1 (2) | 61 (40) | 1 (1) |
Acne | 29 (34) | 6 (7) | 22 (37) | 8 (14) | 55 (36) | 15 (10) |
Alopecia | 25 (29) | 1 (1) | 26 (44) | 2 (3) | 52 (34) | 3 (2) |
Paronychia | 20 (23) | 6 (7) | 15 (25) | 2 (3) | 38 (25) | 10 (6) |
Conjunctivitis | 23 (27) | 1 (1) | 8 (14) | 1 (2) | 33 (21) | 3 (2) |
Dermatitis acneiform | 19 (22) | 5 (6) | 13 (22) | 3 (5) | 33 (21) | 8 (5) |
Skin fissures | 20 (23) | 3 (3) | 10 (17) | 1 (2) | 32 (21) | 4 (3) |
Pruritus | 21 (24) | 1 (1) | 8 (14) | 0 (0) | 30 (19) | 1 (1) |
PPE syndrome | 12 (14) | 1 (1) | 13 (22) | 2 (3) | 25 (16) | 3 (2) |
Skin toxicity | 14 (16) | 4 (5) | 4 (7) | 1 (2) | 18 (12) | 5 (3) |
Erythema | 10 (12) | 2 (2) | 4 (7) | 1 (2) | 16 (10) | 3 (2) |