Skip to main content

Table 3 Analysis of polymorphisms stratified by histological type

From: Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1metabolic genes and risk of lung cancer in Asturias

 

Squamous cell carcinoma

Adenocarcinoma

Small cell carcinoma

 

Ca/Co

pa

Unadj. OR

Adj.bOR

Ca/Co

pa

Unadj. OR

Adj.bOR

Ca/Co

pa

Unadj. OR

Adj.bOR

[95% CI]

[95% CI]

[95% CI]

[95% CI]

[95% CI]

[95% CI]

CYP1A1 MspI T6235C

T/T

238/247

0.384

Reference

Reference

194/193

0.909

Reference

Reference

96/108

0.070

Reference

Reference

T/C + C/C

73/64

1.18

1.38

47/48

0.97

0.83

34/22

1.74

1.45

[0.81-1.73]

[0.86-2.20]

[0.62-1.53]

[0.50-1.35]

[0.95-3.19]

[0.74-2.85]

GSTM 1 present/null

present/present

160/142

0.147

Reference

Reference

109/113

0.712

Reference

Reference

56/59

0.706

Reference

Reference

> = 1 null allele

149/167

1.00

0.91

126/122

1.07

0.96

72/69

1.10

1.18

[0.58-1.09]

[0.63-1.33]

[0.75-1.54]

[0.65-1.44]

[0.67-1.80]

[0.67-2.09]

GSTT 1 present/null

present/present

243/239

0.698

Reference

Reference

193/186

0.414

Reference

Reference

103/103

1.000

Reference

Reference

> = 1 null allele

66/70

0.93

0.83

42/49

0.83 [0.52-1.31]

0.76 [0.46-1.26]

25/25

1.00

1.18

[0.63-1.36]

[0.53-1.30]

[0.54-1.86]

[0.58-2.40]

GSTP 1 Ile105Val

Ile/Ile

132/143

0.374

Reference

Reference

115/102

0.235

Reference

Reference

59/44

0.057

Reference

Reference

Ile/Val+Val/Val

179/168

1.15

1.12

127/140

0.80

0.69

71/86

0.62

0.61

[0.84-1.59]

[0.76-1.63]

[0.56-1.15]

[0.46-1.02]

[0.37-1.02]

[0.34-1.08]

  1. a Chi-squared p-value.
  2. b Adjusted by age, pack-years (non-smoker, <37PY, ≥37PY), family history of any cancer, and worker in list A occupation*.
  3. * List A includes occupations known to be associated with lung cancer.
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us