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Table 3 Analysis of polymorphisms stratified by histological type

From: Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1metabolic genes and risk of lung cancer in Asturias

  Squamous cell carcinoma Adenocarcinoma Small cell carcinoma
  Ca/Co pa Unadj. OR Adj.bOR Ca/Co pa Unadj. OR Adj.bOR Ca/Co pa Unadj. OR Adj.bOR
[95% CI] [95% CI] [95% CI] [95% CI] [95% CI] [95% CI]
CYP1A1 MspI T6235C
T/T 238/247 0.384 Reference Reference 194/193 0.909 Reference Reference 96/108 0.070 Reference Reference
T/C + C/C 73/64 1.18 1.38 47/48 0.97 0.83 34/22 1.74 1.45
[0.81-1.73] [0.86-2.20] [0.62-1.53] [0.50-1.35] [0.95-3.19] [0.74-2.85]
GSTM 1 present/null
present/present 160/142 0.147 Reference Reference 109/113 0.712 Reference Reference 56/59 0.706 Reference Reference
> = 1 null allele 149/167 1.00 0.91 126/122 1.07 0.96 72/69 1.10 1.18
[0.58-1.09] [0.63-1.33] [0.75-1.54] [0.65-1.44] [0.67-1.80] [0.67-2.09]
GSTT 1 present/null
present/present 243/239 0.698 Reference Reference 193/186 0.414 Reference Reference 103/103 1.000 Reference Reference
> = 1 null allele 66/70 0.93 0.83 42/49 0.83 [0.52-1.31] 0.76 [0.46-1.26] 25/25 1.00 1.18
[0.63-1.36] [0.53-1.30] [0.54-1.86] [0.58-2.40]
GSTP 1 Ile105Val
Ile/Ile 132/143 0.374 Reference Reference 115/102 0.235 Reference Reference 59/44 0.057 Reference Reference
Ile/Val+Val/Val 179/168 1.15 1.12 127/140 0.80 0.69 71/86 0.62 0.61
[0.84-1.59] [0.76-1.63] [0.56-1.15] [0.46-1.02] [0.37-1.02] [0.34-1.08]
  1. a Chi-squared p-value.
  2. b Adjusted by age, pack-years (non-smoker, <37PY, ≥37PY), family history of any cancer, and worker in list A occupation*.
  3. * List A includes occupations known to be associated with lung cancer.