Table 5 Serum DNA fragments, integrity index and mesothelin in subjects with malignant and benign pleural effusions
| Â | All MPE(n= 52) | MPM (n = 16) | Lung cancer (n=22) | Other cancers (n=14) | BPE(n= 23) | |
|---|---|---|---|---|---|---|
ALU 115 (ng/ml) | p-value | 0.599 | 0.198 | 0.855 | 0.777 | Â |
|  | Mean, Range | 796.7 (6 – 5438) | 503.7 (23 – 2869) | 851.6 (6.3 - 4150.4) | 1072.9 (31.8 – 5438.4) | 826.8 (9 – 3835) |
|  | Median (IQR 25-75) | 234.4 (47.6 – 1107.9) | 123.1 (36.5 – 321.4) | 431.6 (47.1 – 1240.3) | 500.2 (88.6 – 1113.8) | 695.4 (59.1 – 1238.9) |
ALU 247 (ng/ml) | p-value | 0.968 | 0.667 | 0.955 | 0.512 | Â |
|  | Mean, Range | 1088.3 (0 – 11995) | 566.9 (10 – 3520) | 1084.9 (0.1 – 7220.6) | 1689.0 (11.7 – 11995.4) | 930.7(2 – 2946) |
|  | Median (IQR 25-75) | 226.1 (31.6 – 1161.5) | 157.7 (16.6 – 274.7) | 333.6 (26.3 – 1458.4) | 309.8 (50.7 – 1853.7) | 330.2 (8.8 – 1832.7) |
DNA integrity index | p-value | 0.461 | 0.408 | 0.849 | 0.409 | Â |
|  | Mean, Range | 1.0 (0 – 4.1) | 1.1 (0.3 – 4.1) | 0.9 (0.0 – 2.1) | 1.1 (0.3 – 2.2) | 1.0 (0 – 4.2) |
|  | Median (IQR 25-75) | 0.9 (0.5 – 1.3) | 1.0 (0.5 – 1.2) | 1.0 (0.4 – 1.3) | 1.0 (0.6 – 1.5) | 0.9 (0.5 – 1.0) |
Mesothelin, nM | p-value | 0.071 | <0.001 | 0.692 | 0.552 | Â |
|  | Mean, Range | 2.5 (0 - 32) | 4.9 (1- 32) | 1.2 (0 – 5) | 1.2 (0.4 – 3.2) | 1.0 (0 – 4) |
|  | Median (IQR 25-75) | 1.2 (0.7 – 2.2) | 2.0 (1.3 – 3.5) | 0.7 (0.5 – 1.3) | 1.0 (0.6 – 1.6) | 0.8 (0.5 – 1.2) |