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Table 3 Pleural fluid DNA fragments, integrity index and mesothelin in subjects with malignant and benign pleural effusions

From: Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

  

All MPE(n= 52)

Malignant pleural mesothelioma only (n = 16)

Lung cancer (n=22)

Other cancers (n=14)

BPE(n= 23)

ALU 115 (ng/ml)

p-value

0.217

0.509

0.147

0.526

 
 

Mean, Range

1841.6

1512.2

2065.0

1836.6

1616.7

  

(21.8-6328.7)

(41.7 – 5964.2)

(21.8 – 6204.8)

(176.5 – 6328.7)

(48.5 – 7814.9)

 

Median (IQR 25-75)

963.9

712.3

1366.5

723.5

520.3

  

(411.1-2385.7)

(502.3 – 1992.9)

(488.4 – 2624.0)

(299.1 – 4492.1)

(128.6 – 2481.9)

ALU 247 (ng/ml)

p-value

0.066

0.187

0.061

0.231

 
 

Mean, Range

2065.7

1827.6

1947.8

2694.1

1389.4

  

(23.5 – 9973.7)

(23.5 – 7220)

(71.5 – 6671.4)

(151.7 – 9973.7)

(8.2 – 7126)

 

Median (IQR 25-75)

1186.2

1047.8

1368.0

1060.4

371.8

  

(397.7 – 2616.5)

(580.7 – 2353.7)

(346.9 – 2660.3)

(267.4 – 6894.9)

(85.5 – 2036.6)

DNA integrity index

p-value

<0.001

<0.001

0.018

<0.001

 
 

Mean, Range

1.2

1.2

1.09

1.25

0.8

  

(0.4 – 3.3)

(0.6 – 1.9)

(0.4 – 3.3)

(0.6 – 1.8)

(0.0 – 1.5)

 

Median (IQR 25-75)

1.1

1.2

0.9

1.3

0.8

  

(0.8 – 1.5)

(0.9 – 1.6)

(0.7 – 1.2)

(0.9 – 1.6)

(0.7 – 0.9)

Mesothelin, nM

p-value

0.242

<0.001

0.533

0.132

 
 

Mean, Range

36.9

104.2

8.0

5.5

7.4

  

(1-392)

(4 – 392)

(1-31)

(0.7 – 24.5)

(1- 36)

 

Median (IQR 25-75)

6.06

38.0

4.6

3.1

4.6

  

(3.1 – 19.0)

(10.8 – 106.5)

(3 – 11.7)

(1.8 – 8.4)

(2.6 – 8.4)

  1. *p-value-Mann-Whitney U test comparing diagnoses with benign effusions.