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Table 2 Summary of GSEA analysis comparing whole blood gene expression profiles of poor-responders (PR) to responders (R) with regard to pre-RT gene expression levels and response to RT

From: Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

Stress and defence relevant gene set database (keyword) Number of gene sets in collection HNSCC patients whole blood
  HG-U133-plus2 Baseline expression pre-RT Change during RT
   PR > R R > PR PR > R R > PR
Apoptosis 273 29 0 0 91
Cell and cycle 311 38 1 0 85
Cytokine* 239 41 0 0 89
Hypoxi* 63 5 0 0 25
Antioxidant* 10 8 0 0 4
Immune* and response 116 10 0 0 37
Stress and response 59 5 0 0 11
DNA and repair 80 12 0 0 13
Cancer 699 75 1 4 152
Tox* 136 23 0 1 49
C3 TFT 583 18 11 0 4
  1. The number of stress and defence-relevant gene sets that were higher expressed in one group compared to the other are given for each gene set collection. FDR (false discovery rate) < 5%.
  2. Affymetrix HG-U133-plus2 chips were used to analyze the whole blood RNA. A gene set browser provided by Broad institute at www.broad.mit.edu/gsea/ was used to obtain the stress-associated gene set collections. Detailed information regarding the regulated gene sets is given in online Additional files 2-5. *indicates that truncated search keywords were used to create the gene set collections. C3TFT is a pre-defined gene set collections.