Characteristic | Pemetrexed/BSC (n = 28) | BSC alone (n = 27) |
---|---|---|
Median age (range), years | 61 (22-75) | 59 (48-83) |
Males, n (%) | 20 (71.4) | 17 (63.0) |
Race, n (%) | ||
Caucasian | 26 (92.9) | 26 (96.3) |
African | 2 (7.1) | 1 (3.7) |
ECOG PS, n (%) | ||
0 | 8 (28.6) | 6 (22.2) |
1 | 20 (71.4) | 21 (77.8) |
Prior therapy, n (%) | ||
Radiotherapy | 2 (7.1) | 1 (3.7) |
Curative surgery | 0 (0.0) | 2 (7.4) |
Disease stageb, n (%) | ||
IIIB | 9 (32.1) | 10 (37.0) |
IV | 19 (67.9) | 17 (63.0) |
Histologic subtype, n (%) | ||
Adenocarcinoma | 19 (67.9) | 21 (77.8) |
Large cell | 8 (28.6) | 5 (18.5) |
Mixed cell | 1 (3.6) | 1 (3.7) |
Smoking status, n (%) | ||
Current smoker | 8 (28.6) | 6 (22.2) |
Former smoker | 8 (28.6) | 11 (40.7) |
Never smoker | 12 (42.9) | 10 (37.0) |
Best tumor response, n (%)c | ||
Complete response (CR) | 0 (0.0) | 1 (3.7) |
Partial response (PR) | 10 (35.7) | 11 (40.7) |
Stable disease (SD) | 17 (60.7) | 13 (48.1 |
Unknown | 1 (3.6) | 2 (7.4) |