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Table 3 Univariate and multivariable analysis for relative survival stratified by age for patients naive to systemic treatment

From: Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer

Characteristic

Patients < 65 years

Patients > 65 years

  

Univariate analysis

Multivariable analysis

 

Univariate analysis

Multivariable analysis

 

N

RER

95% CI

P

RER

95% CI

P

N

RER

95% CI

P

RER

95% CI

P

Age

   

.06

  

.10

       

< 40

33

1

  

1

  

0

      

40-50

98

1.03

0.51-2.08

 

0.69

0.21-2.24

 

0

      

50-60

101

1.52

0.76-3.03

 

1.38

0.46-5.18

 

0

      

> 60

44

2.16

0.99-4.66

 

1.93

0.56-6.57

 

154

      

Grade

   

.03

  

.95

   

.34

   

I

31

1

  

1

  

24

1

     

II

131

2.23

0.80-6.28

 

1.24

0.31-5.03

 

74

3.10

0.43-22.4

    

III

75

3.48

1.22-9.94

 

1.27

0.30-5.45

 

44

4.23

0.56-31.8

    

Histological type

   

.80

      

.37

   

Ductal

223

1

     

124

1

     

Other

15

1.12

0.46-2.71

    

18

1.49

0.62-3.61

    

Tumor stage

   

< .001

  

.33

   

.01

  

.09

pT1

137

1

  

1

  

59

1

  

1.00

  

pT2

109

2.67

1.41-3.64

 

1.42

0.73-2.76

 

71

5.47

0.83-35.9

 

4.26

0.71-25.4

 

pT3/4

22

4.26

2.29-7.94

 

1.79

0.81-3.95

 

18

13.2

1.90-92.1

 

7.90

1.18-52.9

 

Nodal stage

   

< .001

  

< .001

   

.02

  

.43

Negative

204

1

  

1

  

109

1

  

1.00

  

Positive

69

5.03

3.32-7.62

 

5.82

3.16-10.7

 

36

2.76

1.20-6.35

 

1.48

0.56-3.92

 

ER status

   

.11

      

.91

   

Negative

87

1

     

40

1

     

Positive

126

0.70

0.45-1.09

    

95

0.95

0.42-2.17

    

PgR status

   

.25

      

.58

   

Negative

84

1

     

55

1

     

Positive

123

0.77

0.49-1.21

    

81

0.80

0.36-1.77

    

HER2 status

   

.19

      

.89

   

Negative

143

1

     

105

1

     

Positive

19

1.57

0.80-3.09

    

4

0.85

0.09-8.40

    

ALDH1 status

   

.008

  

.02

   

.35

   

Negative

77

1

  

1

  

63

1

     

Positive

116

2.12

1.22-3.68

 

2.36

1.17-4.73

 

61

0.68

0.30-1.53

    
  1. Abbreviations: N number of patients; RER relative excess risk; ER estrogen receptor; PgR progesterone receptor; HER2 human epidermal growth factor receptor 2; ALDH1 aldehyde dehydrogenase 1