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Table 3 Univariate and multivariable analysis for relative survival stratified by age for patients naive to systemic treatment

From: Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer

Characteristic Patients < 65 years Patients > 65 years
   Univariate analysis Multivariable analysis   Univariate analysis Multivariable analysis
  N RER 95% CI P RER 95% CI P N RER 95% CI P RER 95% CI P
Age     .06    .10        
< 40 33 1    1    0       
40-50 98 1.03 0.51-2.08   0.69 0.21-2.24   0       
50-60 101 1.52 0.76-3.03   1.38 0.46-5.18   0       
> 60 44 2.16 0.99-4.66   1.93 0.56-6.57   154       
Grade     .03    .95     .34    
I 31 1    1    24 1      
II 131 2.23 0.80-6.28   1.24 0.31-5.03   74 3.10 0.43-22.4     
III 75 3.48 1.22-9.94   1.27 0.30-5.45   44 4.23 0.56-31.8     
Histological type     .80        .37    
Ductal 223 1       124 1      
Other 15 1.12 0.46-2.71      18 1.49 0.62-3.61     
Tumor stage     < .001    .33     .01    .09
pT1 137 1    1    59 1    1.00   
pT2 109 2.67 1.41-3.64   1.42 0.73-2.76   71 5.47 0.83-35.9   4.26 0.71-25.4  
pT3/4 22 4.26 2.29-7.94   1.79 0.81-3.95   18 13.2 1.90-92.1   7.90 1.18-52.9  
Nodal stage     < .001    < .001     .02    .43
Negative 204 1    1    109 1    1.00   
Positive 69 5.03 3.32-7.62   5.82 3.16-10.7   36 2.76 1.20-6.35   1.48 0.56-3.92  
ER status     .11        .91    
Negative 87 1       40 1      
Positive 126 0.70 0.45-1.09      95 0.95 0.42-2.17     
PgR status     .25        .58    
Negative 84 1       55 1      
Positive 123 0.77 0.49-1.21      81 0.80 0.36-1.77     
HER2 status     .19        .89    
Negative 143 1       105 1      
Positive 19 1.57 0.80-3.09      4 0.85 0.09-8.40     
ALDH1 status     .008    .02     .35    
Negative 77 1    1    63 1      
Positive 116 2.12 1.22-3.68   2.36 1.17-4.73   61 0.68 0.30-1.53     
  1. Abbreviations: N number of patients; RER relative excess risk; ER estrogen receptor; PgR progesterone receptor; HER2 human epidermal growth factor receptor 2; ALDH1 aldehyde dehydrogenase 1