Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

Table 7 Cox proportional hazard models (59 patients without lymph node metastasis)

Variable	Crude HR	95% CI	P value	AHR	95% CI	P value
PIK3CA amplification	2.83	1.08-7.36	0.003	3.13	1.16-8.4	0.024
Mutation (PIK3CA K-Ras)	0.73	0.09-5.6	0.77	0.83	0.1-6.78	0.86
Age	0.97	0.93-1.00	0.13	0.95	0.91-1.0	0.075
Gender	1.22	0.52-2.84	0.64	1.06	0.42-2.65	0.89
Smoking status	1.01	0.99-1.03	0.08	1.02	0.99-1.04	0.06

Adjusted for age, gender, smoking status, mutation status.
HR, hazard ratio; CI, confidence interval; AHR, adjusted hazard ratio.
Cox proportional hazard models were computed to determine the significance of PIK3CA amplification with adjustment for age, gender, smoking status and mutation status.

ISSN: 1471-2407