Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

Table 6 Patients’ characteristics stratified by Copy number alternation of PIC3CA

Variable	Copy number of PIK3CA (Not Amplified n = 78)	Copy number of PIK3CA (Amplification n = 37)	P value
Age: mean ± SD	64.8 ± 11.6	65.6 ± 9.9	0.60^*
Sex: Male/Female	63 / 15	30 / 7	0.96^†
Number of metastatic
Lymph nodes:	0/0/1.5	0/0/0	0.65^‡
25%/50%/75%	0/0/1.5	0/0/0	0.65^‡
Primary site			0.39^†
Oropharyngeal	15(19.2%)	10(27.0%)
Hypopharyngeal	16(20.5%)	9(24.3%)
Laryngeal	15(19.2%)	8(21.6%)
Oral cavity	22(28.2%)	9(24.3%)
Nasal cavity	10(12.8%)	1(2.7%)
Tumor grade:	28/35/15	18/12/7	0.37^†
well/ moderate/poor	(35.9%/44.9%/19.2%)	(48.6%/32.4%/18.9%)	0.37^†
TNM classification
T stage: T1/T2/T3/T4	12/30/17/19	4/15/10/8	0.85^†
T stage: T1/T2/T3/T4	(15.3%/38.5%/21.8%/24.4%)	(10.8%/40.5%/ 27.0%/21.6%)	0.85^†
N stage: N0/N1/N2	43/12/23	16/5/16	0.34^†
N stage: N0/N1/N2	(55.1%/15.4%/29.5%)	(43.2%/13.5%/43.2%)	0.34^†
Stage : I/ II/III/IV	11/16/17/34	1/7/9/20	0.28^†
Stage : I/ II/III/IV	(14.1%/20.5%/21.8%/43.6%)	(2.7%/18.9%/ 24.3%/54.1%)	0.28^†
Pack-year(tobacco) mean ± SD	19.6 ± 24.3	22.3 ± 24.6	0.64^*

^* Student t test † Chi-square test ‡ Fisher test.
The patients’ characteristics stratified by the PIK3CA copy number alteration. There was no significant association.

ISSN: 1471-2407