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Table 4 HNSCC gene mutations

From: Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

No

Nucleotide change

Amino acid Change

Primary tumor

Exon

Smoking (pack/year)

Age/Sex

12

Substitution of G for C at nucleotide 35

G12A

Oral Cavity (T3N0M0)

KRAS Exon1

45

51/M

21

Substitution of G for C at nucleotide 35

G12A

Oropharyngeal (T2N0M0)

KRAS Exon1

10

47 /M

30

Substitution of G for C at nucleotide 35

G12A

Oral Cavity (T3N1M0)

KRAS Exon1

0

54/M

10

Substitution of A for G at nucleotide 3140

H1047R

Laryngeal (T3N0M0)

PIK3CA Exon20

0

61/M

51

Substitution of G for A at nucleotide 1633

E545K

Oral Cavity (T1N1M0)

PIK3CA Exon9

0

79/M

53

Substitution of G for A at nucleotide 1633

E545K

Oral Cavity (T3N0M0)

PIK3CA Exon9

0

82/M

  1. We sequenced KRAS exon 1, BRAF exon 15 and PIK3CA exon 9 and exon 20 and identified mutations in six of the 115 patients (5.2%).
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