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Table 1 Genes modulated by simvastatin in PC3 cells as identified by qRT-PCR arrays

From: Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis

GeneBank

Symbol

Description

Change (X fold)

NM_030693

Atf5

Activating transcription factor 5

2.0↓

NM_009741

Bcl2

B-cell leukemia/lymphoma 2

2.0↓

NM_009743

Bcl2l1/2

Bcl2-like 1 and 2

1.7↓

NM_013479

Bcl2l10

Bcl2-like 10

2.0↓

NM_008670

Birc1a

Baculoviral IAP repeat-containing 1a

2.4↑

NM_007464

Birc3

Baculoviral IAP repeat-containing 3

1.6↑

NM_009689

Birc5

Baculoviral IAP repeat-containing 5

3.0↑

NM_009807

Casp1

Caspase 1

2.8↑

NM_007702

Cidea

Cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

1.6↑

NM_010015

Dad1

Defender against cell death 1

2.5↓

NM_010175

Fadd

Fas (TNFRSF6)-associated via death domain

2.0↑

NM_010177

Fasl

Fas ligand (TNF superfamily, member 6)

1.9↑

NM_010548

Il10

Interleukin 10

1.6↑

NM_010712

Lhx4

LIM homeobox protein 4

3.3↓

NM_080637

Nme5

Non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)

1.8↓

NM_030152

Nol3

Nucleolar protein 3 (apoptosis repressor with CARD domain)

1.6↓

NM_023258

Pycard

PYD and CARD domain containing

2.0↓

NM_013693

Tnf

Tumor necrosis factor

3.2↑

NM_020275

Tnfrsf10b

Tumor necrosis factor receptor superfamily, member 10b

1.6↑

NM_011611

Cd40

CD40 antigen

3.5↑

NM_009425

Tnfsf10

Tumor necrosis factor (ligand) superfamily, member 10

1.6↑

NM_011617

Cd70

CD70 antigen

3.3↑

NM_009421

Traf1

Tnf receptor-associated factor 1

4.0↑

NM_021897

Trp53inp1

Transformation related protein 53 inducible nuclear protein 1

3.2↑