Figure 2

Simvastatin inhibits Bcl-2- and Bcl-xL-mediated cell survival pathway in prostate cancer cells. (A) Western blots showing reduced phosphorylation of Bad, reduced protein expression of Bcl-2 and Bcl-xL as well as increased protein expression of BimL/BimS, cleaved caspase 9 and cleaved caspase 3 after 24 h treatment with simvastatin, docetaxel or a combination of both, compared to saline treated control (B) Bar graph showing quantification of the above data by densitometry analysis normalized to β-actin. The data are presented as mean ± SD (n=4 of quadruplicate experiments).