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Table 3 IC 50 of proliferation of eltrombopag on breast, lung, and ovarian tumor cell lines

From: Low or undetectable TPO receptor expression in malignant tissue and cell lines derived from breast, lung, and ovarian tumors

Cell line

Tumor type

IC50(μg/mL)

MCF-7

Breast carcinoma

19.0

BT474

Breast carcinoma

9.6

HCC1937

Breast carcinoma

10.7

A549

Lung alveolar cell carcinoma

9.0

NCI-H226

Lung squamous cell carcinoma

3.7

NCI-H460

Large cell lung carcinoma

8.1

NCI-H510

Small cell lung carcinoma

10.3

OVCAR3

Ovarian adenocarcinoma

4.8

OVCAR4

Ovarian carcinoma

11.0

SKOV-3

Ovarian adenocarcinoma

49.7