TY - JOUR AU - Petty, W. Jeffrey AU - Aklilu, Mebea AU - Varela, Victor A. AU - Lovato, James AU - Savage, Paul D. AU - Miller, Antonius A. PY - 2012 DA - 2012/09/11 TI - Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas JO - BMC Cancer SP - 404 VL - 12 IS - 1 AB - In a phase I study of angiotensin-(1–7) [Ang-(1–7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1–7) induced changes in biomarkers according to cancer type and investigates mechanisms of action engaged in vitro. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-12-404 DO - 10.1186/1471-2407-12-404 ID - Petty2012 ER -