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Table 3 Cox univariate and multivariate analysis of distant disease-free survival

From: Analysis of and prognostic information from disseminated tumour cells in bone marrow in primary breast cancer: a prospective observational study

  Univariate analysis (n ≤ 401) Multivariate analysis (n = 377)
Variable HR* 95% CI p-value HR** 95% CI p-value
DTC status (IF and IC) (n=401) DTC+ vs DTC- 1.2 0.66-2.2 0.55    
DTC status (IF) (n=327) 1.2 0.63- 2.2 0.60    
DTC+ vs DTC-    
DTC statuc (IC) (n=74) DTC+ vs DTC- 0.84 0.09-8.1 0.88    
Age 0.99 0.97-1.02 0.61    
per year    
Node status 5.5 2.7- 11 < 0.001 3.4 1.6- 7.2 0.001
N+ vs N0
Tumor size 4.9 2.6-9.4 < 0.001 2.5 1.2- 5.2 0.01
> 20 mm vs ≤ 20 mm
NHG status 6.9 0.92-52 0.06 4.9 0.65-37 0.12
NHG 2 vs NHG 1
NHG 3 vs NHG 1 20 2.7- 147 0.004 8.7 1.1- 70 0.04
ER status 0.39 0.21-0.72 0.003 0.85 0.38- 1.9 0.7
ER+ vs ER-
PR status 0.43 0.24- 0.79 0.007 0.67 0.33- 1.4 0.3
PR+ vs PR-       
  1. * No significant deviations from proportional hazards (Schoenfeld’s test).
  2. * *P=0.05 in Schoenfeld’s global six degree-of-freedom test of proportional hazards.
  3. Abbreviations: IF= immunofluorescence, IC=immunocytochemistry, HR= hazard ratio, CI= confidence interval, DTC= disseminated tumor cells, N0= node negative, N+= node positive, NHG= Nottingham histological grade, ER= oestrogen receptor, PR= progesterone receptor.