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Table 2 Patient`s and tumor characteristics in relation to presence of DTC in bone marrow

From: Analysis of and prognostic information from disseminated tumour cells in bone marrow in primary breast cancer: a prospective observational study

Characteristics Patients analyzed by IF No DTC in bone marrow N (%) DTC in bone marrow N (%) p-value* Patients analyzed by IC No DTC in bone marrow N (%) DTC in bone marrow N (%) p-value*
Tumor size         
≤ 20 mm 203 118 (58) 85 (42) 0.3 60 42 (70) 18 (30) 1.0
> 20 mm 123 78 (63) 45 (37)   13 9 (69) 4 (31)  
Node status         
N0 184 113 (61) 71 (39) 0.5 49 35 (71) 14 (29) 0.7
N+ 133 77 (58) 56 (42)   24 16 (67) 8 (33)  
NHG         
1 60 30 (50) 30 (50)   17 13 (76) 4 (24)  
2 181 110 (61) 71 (39) 0.12 40 24 (60) 16 (40) 0.7
3 80 51 (64) 29 (36)   14 12 (86) 2 (14)  
ER status         
Positive 252 145 (58) 107 (42) 0.12 60 41 (68) 19 (32) 0.8
Negative 66 45 (68) 21 (32)   11 8 (73) 3 (27)  
PR status         
Positive 189 110 (58) 79 (42) 0.5 53 37 (70) 16 (30) 0.8
Negative 129 80 (62) 49 (38)   18 12 (67) 6 (33)  
  1. * X 2-test for two categories and X 2-test for trend for three ordered categories.
  2. Abbreviations: IF= immunofluorescence, IC=immunocytochemistry, DTC= disseminated tumor cells, N0= node negative, N+=node positive, NHG= Nottingham histological grade, ER= oestrogen receptor, PR= progesterone receptor.