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Figure 9 | BMC Cancer

Figure 9

From: HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

Figure 9

A and B: Immunohistochemical staining for CD44 in formalin fixed paraffin embedded MCF7 cell monolayers under normoxic conditions. . (MCF7 control cells) (A, bar 4 microns) and in MCF7 3D-spheroids (B, bar 4 microns). Spheroids formation induced de novo acquisition of CD44 that was visible on the cell membrane. C and D: Immunohistochemical for p53. Only few nuclei of MCF-7 control cells were positive (C, bar 40 microns), while a higher number of positive nuclei were present in MCF7 3D-spheroids (D, bar 40 microns).

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