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Table 4 Comparison of Diagnostic Performance of NAB alone and NAB with Tumor Markers in 194 patients

From: Additional diagnostic value of tumor markers in cytological fluid for diagnosis of non-small-cell lung cancer

Tumor marker AUC P-value
NAB alone 0.917 (95%CI;0.886-0.948)  
NAB with Serum tumor marker
CYFRA (3.3) 0.837 (95%CI;0.778-0.896) 0.009
CEA (5) 0.886 (95%CI;0.838-0.934) 0.408
SCC (2) 0.885 (95%CI;0.838-0.901) 0.207
NAB with Cytological tumor marker
CYFRA (15.7) 0.966 (95%CI;0.940-0.991) 0.009
CEA (0.6) 0.924 (95%CI;0.883-0.965) 0.999
SCC (0.86) 0.811 (95%CI;0.746-0.876) 0.003
  1. Note-Numbers in parentheses are cut-off levels of tumor markers in ng/mL
  2. Abbreviations: PPV, positive predictive value; NPV, negative predictive value; CEA, carcinoembryonic antigen; SCC, squamous cell carcinoma; CYFRA, cytokeratin 19 fragments; NAB, needle aspiration biopsy; AUC, areas under the curve.