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Table 1 Gene expression profiling in MDA-MB-231 cells incubated with or without paclitaxel (tax) or epirubicin (epi) under normoxic (N) or hypoxic (H) conditions

From: TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

 

Fold Induction

Standard Deviation

Fold Induction

Standard Deviation

Fold Induction

Standard Deviation

Fold Induction

Standard Deviation

Fold Induction

Standard Deviation

Fold Induction

Standard Deviation

H tax / N tax

P values

H epi / N epi

 

N

H

N tax

H tax

N epi

H epi

 

H tax vs N tax

 

SPAG4

1

0.23

84.19

0.07

0.73

0.14

38.57

0.17

1.86

0.07

1.47

0.43

52.76

4.88E-05

0.79

ALDOC

1

0.39

91.10

0.17

0.46

0.07

22.20

0.23

0.73

0.16

0.86

0.25

48.31

0.0002552

1.18

ANGPTL4

1

0.03

53.47

0.19

0.80

0.19

26.54

0.35

0.67

0.04

0.69

0.00

33.10

0.0006633

1.02

PFKFB4

1

0.12

12.11

0.05

0.51

0.03

11.73

0.15

0.04

0.09

0.04

0.01

23.12

0.0001621

0.94

C10orf10 probe set 1

1

0.15

69.43

0.30

0.86

0.03

18.27

0.43

0.87

0.03

0.87

0.01

21.19

0.0019277

1.00

TMEM45A

1

0.59

106.19

0.01

5.13

0.29

86.65

0.21

8.80

0.31

10.01

0.18

16.88

0.0002627

1.14

RASSF4 probe set 1

1

0.09

11.21

0.15

0.40

0.02

5.86

0.32

0.15

0.74

0.06

0.29

14.65

0.0004547

0.42

ANKRD37

1

0.18

21.08

0.15

1.92

0.14

21.56

0.23

0.19

0.70

0.14

0.10

11.26

0.0001464

0.71

PDK1 probe set 1

1

0.05

8.58

0.13

1.12

0.03

9.01

0.26

3.03

0.07

3.34

0.04

8.06

0.0004021

1.10

PDK1 probe set 2

1

0.18

9.08

0.27

1.36

0.16

10.98

0.40

4.13

0.24

3.56

0.04

8.05

0.0039759

0.86

BNIP3 probe set 1

1

0.05

10.33

0.13

1.39

0.07

10.62

0.20

1.85

0.09

1.87

0.13

7.66

0.0004483

1.01

NDRG1

1

0.21

10.01

0.08

1.23

0.15

9.28

0.12

0.35

0.23

0.27

0.07

7.51

6.10E-05

0.78

RASSF4 probe set 2

1

0.03

9.04

0.10

0.73

0.02

5.05

0.37

0.79

0.06

0.81

0.15

6.91

0.0023704

1.03

AK3L1

1

0.04

3.91

0.07

0.36

0.08

2.26

0.08

1.84

0.05

2.34

0.06

6.32

0.0003084

1.27

WFDC3

1

0.23

8.94

0.31

0.39

0.24

2.46

0.12

0.53

0.37

1.04

0.33

6.28

0.0001468

1.95

P4HA1

1

0.14

10.23

0.05

1.00

0.09

5.60

0.17

1.66

0.15

1.56

0.15

5.59

0.0001797

0.94

MALL

1

0.11

2.64

0.16

0.22

0.19

1.23

0.09

1.07

0.24

1.15

0.12

5.54

0.0001154

1.07

RAB20

1

0.09

4.65

0.02

0.63

0.19

3.33

0.22

0.16

0.23

0.08

0.03

5.32

0.0003267

0.48

EGLN3

1

0.02

13.74

0.17

1.01

0.00

5.14

0.35

0.94

0.09

1.00

0.02

5.09

0.0034448

1.06

FUT11

1

0.23

5.60

0.12

0.49

0.22

2.46

0.16

0.32

0.30

0.21

0.35

5.02

0.0037602

0.67

BNIP3 probe set 2

1

0.09

6.22

0.07

1.25

0.09

6.18

0.13

1.48

0.08

1.58

0.08

4.93

4.93E-05

1.07

PLOD2

1

0.04

7.09

0.11

1.13

0.05

5.45

0.25

2.83

0.20

3.10

0.03

4.83

0.0005200

1.10

PGF

1

0.18

12.21

0.05

0.61

0.22

2.87

0.11

0.39

0.30

0.22

0.25

4.69

0.0008395

0.56

ENO2

1

0.11

5.46

0.06

0.90

0.13

4.17

0.08

2.01

0.10

2.32

0.09

4.66

0.0001298

1.15

TNFSF10

1

0.13

4.11

0.19

0.90

0.52

4.15

0.36

0.98

0.14

1.01

0.09

4.63

0.0026329

1.03

ZNF395

1

0.20

3.30

0.03

0.41

0.25

1.84

0.21

0.78

0.20

0.83

0.20

4.49

0.0009758

1.06

PFKFB3

1

0.00

5.50

0.10

1.17

0.11

5.24

0.32

0.59

0.27

0.33

0.14

4.47

0.0019571

0.56

ANKZF1

1

0.11

6.70

0.07

1.31

0.16

5.77

0.17

0.59

0.15

0.58

0.10

4.40

0.0012567

0.98

JMJD1A

1

0.11

5.36

0.10

2.12

0.02

8.93

0.19

0.35

0.98

0.15

0.22

4.21

0.0017354

0.42

C10orf10 probe set 2

1

0.01

23.38

0.78

1.00

0.00

4.12

0.34

1.01

0.01

1.37

0.45

4.14

0.0020200

1.36

IL24

1

1.42

0.14

0.20

5.70

0.27

0.82

0.60

6.86

1.43

1.07

0.25

0.14

0.0010651

0.16

  1. Cells were incubated in the different conditions for 16 hours before RNA extraction, target preparation, hybridization to Affymetrix HG-U133 Plus 2.0 arrays, washing and array signal acquisition, as described in Material an Methods. Each value of the fold induction columns is the mean of three ratio values calculated from three independent experiments. These 31 candidate genes were selected on the basis of their p value (p < 0.005) and fold change (at least 4 times) between “N tax” and “H tax”. They are italicized if qualitative data (as discussed in Material and Methods).
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