Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract

BMC Cancer

Table 3 Change in physical and psychosocial symptom burden within chemotherapy lines

EORTC QLQ-C30	Adjuvant CT		1st pall. CT		2nd pall. CT		3^rd+pall. CT
	monthly change rate	p	monthly change rate	p	monthly change rate	p	monthly change rate	p
Physical Functioning	3.3	<0.001	−0.1	0.868	−1.2	0.087	−3.0	0.001
Role Functioning	6.8	<0.001	0.0	0.994	−1.7	0.059	−3.2	0.002
Social Functioning	1.9	0.135	1.1	0.071	−1.1	0.110	−2.1	0.019
Emotional Functioning	1.8	0.006	0.6	0.301	−0.5	0.299	−2.3	0.001
Cognitive Functioning	−0.1	0.901	0.1	0.859	−1.2	0.036	−1.4	0.200
Global QOL	4.1	<0.001	0.0	0.955	−0.9	0.166	−1.6	0.012
Fatigue	−3.4	0.009	0.0	0.992	1.3	0.117	3.3	0.002
Pain	−1.1	0.128	−0.1	0.902	0.0	0.952	0.6	0.394
Nausea/Vomiting	−2.4	0.006	−0.9	0.162	−0.6	0.450	2.0	0.105
Dyspnoea	−0.5	0.494	0.4	0.476	0.6	0.506	4.6	0.006
Appetite Loss	−1.8	0.067	−0.2	0.802	−0.7	0.341	3.0	0.030
Sleeping Disturbances	−4.3	0.022	−1.2	0.182	0.9	0.358	2.0	0.055
Constipation	−1.7	0.217	−1.2	0.171	−0.5	0.380	−1.0	0.202
Diarrhoea	0.0	0.986	−0.4	0.445	0.9	0.221	0.1	0.911
Financial Impact	0.7	0.593	0.5	0.322	0.4	0.550	2.4	0.017
Taste Alterations	1.9	0.123	1.8	0.012	1.1	0.136	−0.3	0.749

* Monthly change rates give change estimates in score points per 30 days, based on the mixed effect model.

ISSN: 1471-2407