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Table 3 Change in physical and psychosocial symptom burden within chemotherapy lines

From: Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract

EORTC QLQ-C30 Adjuvant CT 1st pall. CT 2nd pall. CT 3rd+pall. CT
  monthly change rate p monthly change rate p monthly change rate p monthly change rate p
Physical Functioning 3.3 <0.001 −0.1 0.868 −1.2 0.087 −3.0 0.001
Role Functioning 6.8 <0.001 0.0 0.994 −1.7 0.059 −3.2 0.002
Social Functioning 1.9 0.135 1.1 0.071 −1.1 0.110 −2.1 0.019
Emotional Functioning 1.8 0.006 0.6 0.301 −0.5 0.299 −2.3 0.001
Cognitive Functioning −0.1 0.901 0.1 0.859 −1.2 0.036 −1.4 0.200
Global QOL 4.1 <0.001 0.0 0.955 −0.9 0.166 −1.6 0.012
Fatigue −3.4 0.009 0.0 0.992 1.3 0.117 3.3 0.002
Pain −1.1 0.128 −0.1 0.902 0.0 0.952 0.6 0.394
Nausea/Vomiting −2.4 0.006 −0.9 0.162 −0.6 0.450 2.0 0.105
Dyspnoea −0.5 0.494 0.4 0.476 0.6 0.506 4.6 0.006
Appetite Loss −1.8 0.067 −0.2 0.802 −0.7 0.341 3.0 0.030
Sleeping Disturbances −4.3 0.022 −1.2 0.182 0.9 0.358 2.0 0.055
Constipation −1.7 0.217 −1.2 0.171 −0.5 0.380 −1.0 0.202
Diarrhoea 0.0 0.986 −0.4 0.445 0.9 0.221 0.1 0.911
Financial Impact 0.7 0.593 0.5 0.322 0.4 0.550 2.4 0.017
Taste Alterations 1.9 0.123 1.8 0.012 1.1 0.136 −0.3 0.749
  1. * Monthly change rates give change estimates in score points per 30 days, based on the mixed effect model.