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Table 3 Changes in relative intensities of metabolites in response to NAC

From: Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy

  

Survivors (n = 44)

Non-survivors (n = 19)

Metabolite

ppm

Mean ± SE

p-value

Mean ± SE

p-value

Lactate

4.08-4.13

2.8 ± 15.3

0.815

97.1 ± 26.4

0.004**

Glycine

3.54-3.56

-19.6 ± 8.0

0.047*

0.8 ± 14.3

0.601

GPC

3.22-3.24

-59.6 ± 14.6

< 0.001**

-11.8 ± 15.7

0.469

PC

3.21-3.22

-95.4 ± 24.3

< 0.001**

-67.4 ± 44.2

0.227

Cho

3.20-3.21

-16.6 ± 6.3

0.013*

-17.8 ± 6.3

0.084

tCho

3.20-3.24

-167.2 ± 36.7

< 0.001**

-95.3 ± 57.5

0.091

Taurine

3.40-3.43

-0.8 ± 13.2

0.861

6.9 ± 12.5

0.398

β-Glucose

4.61-4.64

17.8 ± 5.1

0.002**

-0.2 ± 8.8

0.841

  1. The values (post- minus pre-treatment) of relative intensities are integrated peak areas from spectra normalized to equal total areas. Wilcoxon sign rank tests were used for paired statistical analyses. *p < 0.05, ** p < 0.01