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Table 3 Changes in relative intensities of metabolites in response to NAC

From: Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy

   Survivors (n = 44) Non-survivors (n = 19)
Metabolite ppm Mean ± SE p-value Mean ± SE p-value
Lactate 4.08-4.13 2.8 ± 15.3 0.815 97.1 ± 26.4 0.004**
Glycine 3.54-3.56 -19.6 ± 8.0 0.047* 0.8 ± 14.3 0.601
GPC 3.22-3.24 -59.6 ± 14.6 < 0.001** -11.8 ± 15.7 0.469
PC 3.21-3.22 -95.4 ± 24.3 < 0.001** -67.4 ± 44.2 0.227
Cho 3.20-3.21 -16.6 ± 6.3 0.013* -17.8 ± 6.3 0.084
tCho 3.20-3.24 -167.2 ± 36.7 < 0.001** -95.3 ± 57.5 0.091
Taurine 3.40-3.43 -0.8 ± 13.2 0.861 6.9 ± 12.5 0.398
β-Glucose 4.61-4.64 17.8 ± 5.1 0.002** -0.2 ± 8.8 0.841
  1. The values (post- minus pre-treatment) of relative intensities are integrated peak areas from spectra normalized to equal total areas. Wilcoxon sign rank tests were used for paired statistical analyses. *p < 0.05, ** p < 0.01