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Table 3 *Adjusted ORs and 95% CI for the relationship between the C-peptide, IGFBP-1 and low apoptosis, among overweight and obese individuals (BMI > 30)

From: Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa

 

Overall

Men

Women

Measure

Apoptosis (n, Lower/upper half)

Adjusted OR1(95% CI)

Apoptosis (n, Lower/upper half)

Adjusted OR1(95% CI)

Apoptosis (n, Lower/upper half)

Adjusted OR1(95% CI)

C-Peptide

      

Quartile 1

12/16

1.0 (Referent)

6/7

1.0 (Referent)

6/9

1.0 (Referent)

Quartile 2

26/20

3.1 (1.0, 9.5)

9/11

4.4 (0.7, 30.0)

17/9

3.9 (0.9, 16.1)

Quartile 3

33/24

2.7 (0.9, 8.1)

17/9

7.0 (1.1,45.3)

16/15

1.9 (0.5, 7.3)

Quartile 4

54/45

2.5 (0.9, 7.1)

30/21

6.3 (1.1, 36.7)

24/24

1.5 (0.4, 5.5)

P trend

 

0.0465

 

0.04

 

0.30

IGFBP-1

      

Quartile 1

51/35

1.0 (Referent)

24/13

1.0 (Referent)

27/22

1.0 (Referent)

Quartile 2

44/33

0.9 (0.5, 1.9)

23/16

0.9 (0.3, 2.6)

21/17

1.0 (0.4, 2.5)

Quartile 3

22/19

0.9 (0.4, 2.1)

12/12

0.5 (0.1, 1.6)

10/7

1.4 (0.4, 4.9)

Quartile 4

8/18

0.3 (0.1, 1.0)

3/7

0.2 (0.03, 1.2)

5/11

0.4 (0.1, 1.5)

P trend

 

0.10

 

0.07

 

0.44

Insulin

      

Quartile 1

11/14

1.0 (Referent)

6/8

1.0 (Referent)

5/6

1.0 (Referent)

Quartile 2

25/17

1.6 (0.5, 5.1)

16/5

2.3 (0.4, 13.1)

9/12

1.1 (0.2, 5.5)

Quartile 3

33/25

1.3 (0.4, 3.9)

17/13

0.7 (0.1, 3.4)

16/12

1.7 (0.3, 8.5)

Quartile 4

40/32

1.5 (0.5, 4.4)

17/10

1.0 (0.2, 4.9)

23/22

1.6 (0.4, 7.1)

P trend

 

0.46

 

0.99

 

0.53

  1. *Adjusted for race, sex, alcohol intake, diabetes history, smoking and red meat intake.