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Table 2 *Adjusted ORs and 95% CI for the relationship between the C-peptide, IGFBP-1 and adenoma status, overall, and among men and women

From: Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa

 

Overall

Men

Women

Measure

Case/control (n)

Adjusted OR1(95% CI)

Case/control (n)

Adjusted OR1(95% CI)

Case/control (n)

Adjusted OR1(95% CI)

C-Peptide

      

Quartile 1

29/106

1.0 (Referent)

14/40

1.0 (Referent)

15/66

1.0 (Referent)

Quartile 2

32/108

1.2 (0.6, 2.1)

19/42

1.9 (0.7, 4.8)

13/66

0.8 (0.3, 2.1)

Quartile 3

40/101

1.4 (0.8, 2.6)

24/40

2.6 (1.0, 6.9)

16/61

1.0 (0.4, 2.4)

Quartile 4

71/105

2.2 (1.2, 4.0)

48/45

4.4 (1.7, 10.9)

23/60

1.6 (0.7, 4.0)

P trend

 

0.04

 

0.006

 

0.58

IGFBP-1

      

Quartile 1

51/106

1.0 (Referent)

36/41

1.0 (Referent)

15/65

1.0 (Referent)

Quartile 2

52/103

0.9 (0.5, 1.6)

35/49

0.7 (0.3, 1.5)

17/54

1.2 (0.5, 3.0)

Quartile 3

37/105

0.7 (0.4, 1.2)

22/42

0.5 (0.2, 1.0)

15/63

1.3 (0.5, 3.1)

Quartile 4

29/105

0.6 (0.3, 1.1)

10/35

0.3 (0.1, 0.7)

19/70

1.4 (0.6, 3.4)

P trend

 

0.13

 

0.007

 

0.47

Insulin

      

Quartile 1

21/88

1.0 (Referent)

14/37

1.0 (Referent)

7/51

1.0 (Referent)

Quartile 2

27/84

1.7 (0.8, 3.7)

17/32

1.3 (0.5, 3.5)

10/52

2.6 (0.7, 9.0)

Quartile 3

40/81

2.6 (1.2, 5.5)

29/31

3.1 (1.2, 7.9)

11/50

2.4 (0.7, 8.6)

Quartile 4

55/84

3.5 (1.7, 7.4)

31/33

2.8 (1.1, 7.1)

24/51

4.6 (1.5, 15.3)

P trend

 

0.002

 

0.02

 

0.03

  1. *Adjusted for race, sex, BMI, WHR, diabetes history, alcohol intake, smoking and red meat intake.