Figure 9
From: Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts
Prolonged sunitinib treatment reduced tumor growth. A, tumor size versus time for untreated and sunitinib-treated A-07-GFP tumors. Points, means of 4 tumors; bars, SEM. Curves, curves fitted to the data by regression analysis. Dotted vertical line indicates time of treatment start. Tumors were initiated 6 days before start of treatment. B-C, vessel density (B), and interstitial distance (C) versus time for untreated and sunitinib-treated A-07-GFP tumors. Points, means of 4 tumors; bars, SEM. D, median blood supply time (BST) for untreated and sunitinib-treated A-07-GFP tumors. Points, individual tumors; horizontal lines, mean BST. P-values are indicated in the panels where statistical tests revealed significant differences between untreated and sunitinib-treated tumors (A-D).