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BMC Cancer

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Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox

  • Benjamin Roche1, 8Email author,
  • Michael E Hochberg2, 3, 8,
  • Aleah F Caulin4,
  • Carlo C Maley5,
  • Robert A Gatenby6,
  • Dorothée Misse7, 8 and
  • Frédéric Thomas7, 8
BMC Cancer201212:387

Received: 30 April 2012

Accepted: 27 August 2012

Published: 3 September 2012

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
30 Apr 2012 Submitted Original manuscript
6 May 2012 Reviewed Reviewer Report - Darryl Shibata
4 Jun 2012 Reviewed Reviewer Report - John Nagy
19 Jul 2012 Author responded Author comments - Benjamin Roche
Resubmission - Version 2
19 Jul 2012 Submitted Manuscript version 2
1 Aug 2012 Reviewed Reviewer Report - Darryl Shibata
Resubmission - Version 3
Submitted Manuscript version 3
27 Aug 2012 Editorially accepted
3 Sep 2012 Article published 10.1186/1471-2407-12-387

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

IRD, UMMISCO (UMI IRD/UPMC), Bondy Cedex, France
ISEM, Institut des Sciences de l’Evolution, Université Montpellier 2, CNRS, Montpellier cedex 5, France
Santa Fe Institute, Santa Fe, USA
Genomics and Computational Biology Graduate Program, University of Pennsylvania, Philadelphia, USA
Center for Evolution and Cancer, Helen Diller Family Comprehensive Cancer Center and Department of Surgery, University of California San Francisco, San Francisco, USA
Departments of Radiology and Integrated Mathematical Oncology, the Moffitt Cancer Center, Tampa, USA
IRD, MIVEGEC (UMR CNRS/IRD/UM1), Montpellier cedex 5, France
CREEC, Universite Montpellier 2, Montpellier Cedex 5, France