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Table 9 Some alternative meta-analyses for current smoking compared to those in Table 8

From: Systematic review with meta-analysis of the epidemiological evidence in the 1900s relating smoking to lung cancer

Analysis description Statisticb All lung cancerc Squamousd Adenoe
As Table 8 a n 195 41 44
  F 9.29 (9.07-9.52) 13.77 (12.75-14.87) 4.77 (4.49-5.07)
  R 8.43 (7.63-9.31) 16.91 (13.14-21.76) 4.21 (3.32-5.34)
  H, PH 13.76, p < 0.001 7.22, p < 0.001 12.28, p < 0.001
Using more precise outcome definitionf n 187 33 40
  F 9.93 (9.68-10.17) 12.74 (11.71-13.87) 4.40 (4.12-4.70)
  R 8.79 (7.97-9.68) 16.43 (12.66-21.32) 4.05 (3.15-5.22)
  H, PH 11.96, p < 0.001 5.70, p < 0.001 12.28, p < 0.001
Using least rather than most adjusted estimates n 195 41 44
  F 9.12 (8.91-9.34) 13.81 (12.79-14.92) 4.82 (4.53-5.12)
  R 8.26 (7.49-9.12) 16.83 (13.12-21.60) 4.27 (3.37-5.40)
  H, PH 13.91, p < 0.001 7.17, p < 0.001 12.33, p < 0.001
Denominator non-smoker rather than never smoker n 188 36 38
  F 3.99 (3.92-4.05) 3.59 (3.42-3.77) 2.65 (250–2.80)
  R 3.75 (3.48-4.03) 4.71 (3.84-5.79) 2.46 (2.07-2.93)
  H, PH 15.67, p < 0.001 12.71, p < 0.001 7.64, p < 0.001
Preferring results for cigarettes to results for any product n 195 41 44
  F 9.47 (9.25-9.69) 13.77 (12.75-14.87) 4.77 (4.49-5.07)
  R 8.64 (7.83-9.54) 16.91 (13.14-21.76) 4.21 (3.32-5.34)
  H, PH 13.72, p < 0.001 7.22, p < 0.001 12.28, p < 0.001
Selecting results for cigarettes onlyg n 38 8 7
  F 9.25 (8.81-9.71) 21.49 (16.73-27.61) 7.18 (5.71-9.04)
  R 9.52 (7.89-11.49) 20.85 (14.84-29.29) 6.05 (3.69-9.92)
  H, PH 10.61, p < 0.001 1.38, NS 2.98, p < 0.1
Selecting results specific for age <56 years n 25 2 3
  F 7.64 (6.69-8.73) 6.48 (2.90-14.52) 0.74 (0.42-1.32)
  R 6.57 (4.68-9.23) 6.48 (2.90-14.52) 0.74 (0.42-1.32)
  H, PH 4.17, p < 0.001 0.33, NS 0.21, NS
Selecting results specific for age 50–70 years n 24 1 0
  F 10.45 (9.65-11.31) 26.42 (9.78-71.36)  
  R 9.62 (7.10-13.05) 26.42 (9.78-71.36)  
  H, PH 9.99, p < 0.001 NA  
Selecting results specific for age 65+ years n 27 0 0
  F 8.79 (8.06-9.58)   
  R 9.07 (6.83-12.04)   
  H, PH 8.37, p < 0.001)   
  1. a See Table 8 for details of the definition of this analysis.
  2. b n = number of estimates combined, F = fixed-effect meta-analysis RR (95% CI), R = random-effects meta-analysis RR (95% CI), H = heterogeneity chisquared per degree of freedom, PH = probability value for heterogeneity expressed as p < 0.001, p < 0.05, p < 0.1 or NS (p ≥ 0.1), PB = probability value for between levels (see Methods) similarly expressed.
  3. c All or nearest available, must include at least squamous cell carcinoma and adenocarcinoma.
  4. d Squamous cell carcinoma or nearest available, but not including adenocarcinoma.
  5. e Adenocarcinoma or nearest available, but not including squamous cell carcinoma.
  6. f Only including results for all lung cancer, squamous cell carcinoma specifically, or adenocarcinoma specifically.
  7. g See also Table 13 (footnote c).