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Table 9 Some alternative meta-analyses for current smoking compared to those in Table 8

From: Systematic review with meta-analysis of the epidemiological evidence in the 1900s relating smoking to lung cancer

Analysis description

Statisticb

All lung cancerc

Squamousd

Adenoe

As Table 8 a

n

195

41

44

 

F

9.29 (9.07-9.52)

13.77 (12.75-14.87)

4.77 (4.49-5.07)

 

R

8.43 (7.63-9.31)

16.91 (13.14-21.76)

4.21 (3.32-5.34)

 

H, PH

13.76, p < 0.001

7.22, p < 0.001

12.28, p < 0.001

Using more precise outcome definitionf

n

187

33

40

 

F

9.93 (9.68-10.17)

12.74 (11.71-13.87)

4.40 (4.12-4.70)

 

R

8.79 (7.97-9.68)

16.43 (12.66-21.32)

4.05 (3.15-5.22)

 

H, PH

11.96, p < 0.001

5.70, p < 0.001

12.28, p < 0.001

Using least rather than most adjusted estimates

n

195

41

44

 

F

9.12 (8.91-9.34)

13.81 (12.79-14.92)

4.82 (4.53-5.12)

 

R

8.26 (7.49-9.12)

16.83 (13.12-21.60)

4.27 (3.37-5.40)

 

H, PH

13.91, p < 0.001

7.17, p < 0.001

12.33, p < 0.001

Denominator non-smoker rather than never smoker

n

188

36

38

 

F

3.99 (3.92-4.05)

3.59 (3.42-3.77)

2.65 (250–2.80)

 

R

3.75 (3.48-4.03)

4.71 (3.84-5.79)

2.46 (2.07-2.93)

 

H, PH

15.67, p < 0.001

12.71, p < 0.001

7.64, p < 0.001

Preferring results for cigarettes to results for any product

n

195

41

44

 

F

9.47 (9.25-9.69)

13.77 (12.75-14.87)

4.77 (4.49-5.07)

 

R

8.64 (7.83-9.54)

16.91 (13.14-21.76)

4.21 (3.32-5.34)

 

H, PH

13.72, p < 0.001

7.22, p < 0.001

12.28, p < 0.001

Selecting results for cigarettes onlyg

n

38

8

7

 

F

9.25 (8.81-9.71)

21.49 (16.73-27.61)

7.18 (5.71-9.04)

 

R

9.52 (7.89-11.49)

20.85 (14.84-29.29)

6.05 (3.69-9.92)

 

H, PH

10.61, p < 0.001

1.38, NS

2.98, p < 0.1

Selecting results specific for age <56 years

n

25

2

3

 

F

7.64 (6.69-8.73)

6.48 (2.90-14.52)

0.74 (0.42-1.32)

 

R

6.57 (4.68-9.23)

6.48 (2.90-14.52)

0.74 (0.42-1.32)

 

H, PH

4.17, p < 0.001

0.33, NS

0.21, NS

Selecting results specific for age 50–70 years

n

24

1

0

 

F

10.45 (9.65-11.31)

26.42 (9.78-71.36)

 
 

R

9.62 (7.10-13.05)

26.42 (9.78-71.36)

 
 

H, PH

9.99, p < 0.001

NA

 

Selecting results specific for age 65+ years

n

27

0

0

 

F

8.79 (8.06-9.58)

  
 

R

9.07 (6.83-12.04)

  
 

H, PH

8.37, p < 0.001)

  
  1. a See Table 8 for details of the definition of this analysis.
  2. b n = number of estimates combined, F = fixed-effect meta-analysis RR (95% CI), R = random-effects meta-analysis RR (95% CI), H = heterogeneity chisquared per degree of freedom, PH = probability value for heterogeneity expressed as p < 0.001, p < 0.05, p < 0.1 or NS (p ≥ 0.1), PB = probability value for between levels (see Methods) similarly expressed.
  3. c All or nearest available, must include at least squamous cell carcinoma and adenocarcinoma.
  4. d Squamous cell carcinoma or nearest available, but not including adenocarcinoma.
  5. e Adenocarcinoma or nearest available, but not including squamous cell carcinoma.
  6. f Only including results for all lung cancer, squamous cell carcinoma specifically, or adenocarcinoma specifically.
  7. g See also Table 13 (footnote c).