Characteristic | Level | Statisticb | All lung cancerc | Squamousd | Adenoe |
---|---|---|---|---|---|
All | All | n | 195 | 41 | 44 |
F | 9.29 (9.07-9.52) | 13.77 (12.75-14.87) | 4.77 (4.49-5.07) | ||
R | 8.43 (7.63-9.31) | 16.91 (13.14-21.76) | 4.21 (3.32-5.34) | ||
H, PH | 13.76, p < 0.001 | 7.22, p < 0.001 | 12.28, p < 0.001 | ||
PE | p < 0.05 | NS | NS | ||
Sex | Male | n | 108 | 22 | 22 |
F | 8.68 (8.36-9.02) | 13.11 (11.85-14.51) | 5.54 (5.04-6.09) | ||
R | 9.16 (8.00-10.49) | 17.73 (12.78-24.59) | 5.56 (4.06-7.61) | ||
Female | n | 68 | 17 | 20 | |
F | 8.06 (7.75-8.38) | 13.44 (11.86-15.23) | 4.40 (4.05-7.79) | ||
R | 6.76 (5.65-8.08) | 14.77 (9.42-23.17) | 3.20 (2.18-4.71) | ||
Combined | n | 19 | 2 | 2 | |
F | 13.19 (12.55-13.86) | 34.23 (23.43-50.00) | 3.11 (2.35-4.11) | ||
R | 12.09 (9.38-15.60) | 34.23 (23.43-50.00) | 3.57 (1.06-12.07) | ||
Between levels | PB | <0.001 | <0.01 | <0.1 | |
Location | North America | n | 84 | 24 | 24 |
F | 12.45 (12.09-12.82) | 17.99 (16.29-19.85) | 7.63 (7.05-8.25) | ||
R | 11.68 (10.61-12.85) | 20.95 (15.41-28.48) | 6.72 (5.50-8.21) | ||
United Kingdom | n | 25 | 0 | 0 | |
F | 6.90 (6.10-7.81) | ||||
R | 7.53 (5.40-10.50) | ||||
Scandinavia | n | 21 | 2 | 2 | |
F | 8.16 (7.30-9.12) | 15.51 (6.63-36.28) | 4.66 (2.67-8.13) | ||
R | 8.68 (7.14-10.54) | 15.51 (6.63-36.28) | 4.69 (2.62-8.40) | ||
Other Europe | n | 23 | 6 | 6 | |
F | 5.88 (5.43-6.38) | 12.22 (10.16-14.69) | 2.65 (2.20-3.18) | ||
R | 8.65 (5.98-12.51) | 13.66 (7.38-25.30) | 3.30 (1.93-5.65) | ||
China | n | 5 | 0 | 0 | |
F | 3.07 (2.56-3.68) | ||||
R | 2.94 (2.23-3.88) | ||||
Japan | n | 18 | 8 | 11 | |
F | 3.68 (3.43-3.95) | 6.85 (5.77-8.13) | 2.11 (1.87-2.37) | ||
R | 3.55 (3.05-4.14) | 11.25 (6.89-18.35) | 1.87 (1.42-2.47) | ||
Other Asia | n | 7 | 0 | 0 | |
F | 2.91 (2.26-3.76) | ||||
R | 2.90 (2.04-4.13) | ||||
Other or multiregion | n | 12 | 1 | 1 | |
F | 7.09 (6.10-8.24) | 10.40 (3.31-32.66) | 7.90 (2.99-20.85) | ||
R | 9.88 (6.89-14.17) | 10.40 (3.31-32.66) | 7.90 (2.99-20.85) | ||
Between levels | PB | <0.001 | NS | <0.001 | |
Start year of study | Before 1960 | n | 22 | 6 | 5 |
F | 6.13 (5.70-6.59) | 6.87 (4.93-9.08) | 3.35 (2.43-4.62) | ||
R | 6.39 (4.70-8.69) | 11.05 (4.07-30.00) | 2.92 (1.17-7.28) | ||
1960-69 | n | 40 | 7 | 7 | |
F | 5.43 (5.12-5.75) | 10.55 (9.07-12.26) | 4.22 (3.76-4.74) | ||
R | 6.44 (5.21-7.95) | 15.48 (7.08-33.83) | 4.55 (2.50-8.30) | ||
1970-79 | n | 41 | 8 | 11 | |
F | 7.27 (6.79-7.79) | 14.53 (12.21-17.29) | 2.99 (2.55-3.50) | ||
R | 7.34 (5.94-9.06) | 16.43 (8.67-31.14) | 3.41 (2.10-5.53) | ||
1980-89 | n | 70 | 18 | 19 | |
F | 12.35 (11.97-12.75) | 16.70 (14.93-18.67) | 6.38 (5.84-6.96) | ||
R | 10.18 (9.02-11.49) | 19.69 (15.08-25.71) | 5.06 (3.65-7.02) | ||
1990 or later | n | 22 | 2 | 2 | |
F | 10.32 (9.10-11.70) | 20.79 (10.16-42.55) | 2.28 (1.63-3.19) | ||
R | 12.81 (8.70-18.85) | 19.39 (6.38-58.88) | 3.62 (0.92-14.29) | ||
Between levels | PB | <0.001 | NS | NS | |
Study type | Case–control | n | 128 | 30 | 34 |
F | 9.69 (9.43-9.95) | 13.59 (12.56-14.70) | 4.71 (4.42-5.01) | ||
R | 8.56 (7.58-9.68) | 16.21 (12.23-21.50) | 3.88 (2.96-5.07) | ||
Prospectivef | n | 67 | 11 | 10 | |
F | 8.04 (7.65-8.46) | 18.87 (12.90-27.59) | 5.93 (4.59-7.66) | ||
R | 8.15 (6.87-9.67) | 19.63 (12.21-31.56) | 5.95 (4.07-8.69) | ||
Between levels | PB | NS | NS | p < 0.1 | |
National cigarette tobacco type | Virginia | n | 34 | 2 | 2 |
F | 6.75 (6.12-7.44) | 31.44 (15.03-65.78) | 6.93 (4.35-11.07) | ||
R | 8.01 (6.16-10.41) | 31.44 (15.03-65.78) | 6.93 (4.35-11.07) | ||
Blended | n | 154 | 39 | 42 | |
F | 9.70 (9.46-9.95) | 13.65 (12.63-14.75) | 4.74 (4.45-5.04) | ||
R | 8.92 (8.01-9.94) | 16.41 (12.68-21.24) | 4.10 (3.21-5.23) | ||
Other | n | 7 | 0 | 0 | |
F | 3.13 (2.64-3.72) | ||||
R | 3.09 (2.50-3.83) | ||||
Between levels | PB | <0.001 | NS | p < 0.1 | |
Any proxy use | Nog | n | 156 | 35 | 38 |
F | 9.24 (9.00-9.48) | 13.09 (12.09-14.18) | 4.67 (4.39-4.98) | ||
R | 8.04 (7.17-9.01) | 15.78 (12.00-20.74) | 3.88 (2.99-5.03) | ||
Yes | n | 39 | 6 | 6 | |
F | 9.68 (9.05-10.36) | 27.96 (20.74-37.69) | 6.88 (5.27-8.97) | ||
R | 10.03 (8.32-12.09) | 27.96 (20.74-37.69) | 6.88 (5.27-8.97) | ||
Between levels | PB | <0.05 | <0.01 | p < 0.01 | |
Full histological confirmation | No | n | 144 | 24 | 23 |
F | 8.87 (8.62-9.12) | 11.53 (10.05-13.23) | 3.99 (3.59-4.43) | ||
R | 7.91 (7.00-8.93) | 19.20 (12.62-29.22) | 5.59 (3.98-7.84) | ||
Yes | n | 51 | 17 | 21 | |
F | 10.45 (9.99-10.92) | 14.94 (13.61-16.40) | 5.25 (4.87-5.67) | ||
R | 10.08 (8.46-12.01) | 14.77 (10.61-20.57) | 3.20 (2.28-4.49) | ||
Between levels | PB | <0.05 | NS | p < 0.05 | |
Number of casesh | 100-249 | n | 56 | 8 | 11 |
F | 5.50 (4.96-6.11) | 5.62 (3.96-7.98) | 2.54 (2.02-3.19) | ||
R | 6.90 (5.46-8.72) | 11.28 (5.08-25.04) | 2.45 (1.54-3.90) | ||
250-499 | n | 48 | 9 | 9 | |
F | 8.47 (7.79-9.22) | 16.67 (11.49-24.18) | 3.20 (2.59-3.95) | ||
R | 8.60 (7.02-10.52) | 17.09 (11.28-25.91) | 3.83 (2.41-6.09) | ||
500-999 | n | 38 | 4 | 4 | |
F | 7.56 (7.04-8.13) | 22.44 (13.58-37.07) | 7.35 (5.12-10.55) | ||
R | 9.54 (7.65-11.89) | 22.44 (13.58-37.07) | 7.35 (5.12-10.55) | ||
1000+ | n | 53 | 20 | 20 | |
F | 10.01 (9.74-10.29) | 14.15 (13.03-15.35) | 5.18 (4.84-5.54) | ||
R | 9.03 (7.63-10.69) | 17.87 (12.92-24.70) | 4.97 (3.54-6.97) | ||
Between levels | PB | NS | NS | p <0.01 | |
Smoking product | Any | n | 85 | 9 | 11 |
F | 8.00 (7.64-8.37) | 17.58 (11.99-25.77) | 2.61 (2.16-3.14) | ||
R | 7.57 (6.47-8.84) | 17.76 (11.75-26.86) | 2.40 (1.59-3.61) | ||
Cigarettes (ignoring | n | 95 | 26 | 28 | |
other products) | F | 9.84 (9.56-10.14) | 13.51 (12.47-14.64) | 5.11 (4.79-5.46) | |
R | 8.95 (7.76-10.33) | 16.43 (12.08-22.33) | 5.02 (3.76-6.70) | ||
Cigarettes only | n | 15 | 6 | 5 | |
F | 9.77 (8.92-10.69) | 17.80 (11.39-27.83) | 5.69 (4.00-8.09) | ||
R | 10.51 (7.70-14.34) | 18.04 (9.79-33.27) | 5.56 (2.61-11.85) | ||
Between levels | PB | NS | NS | p < 0.05 | |
Unexposed base | Never any product | n | 134 | 24 | 27 |
F | 8.80 (8.55-9.06) | 9.80 (8.75-10.98) | 3.01 (2.75-3.29) | ||
R | 8.24 (7.28-9.34) | 14.05 (9.75-20.23) | 3.10 (2.37-4.07) | ||
Never cigarettes | n | 61 | 17 | 17 | |
F | 10.43 (10.00-10.88) | 18.44 (16.60-20.48) | 7.17 (6.59-7.80) | ||
R | 8.89 (7.52-10.51) | 21.71 (16.38-28.76) | 6.61 (4.89-8.95) | ||
Between levels | PB | NS | <0.1 | <0.001 | |
Number of adjustment variables | 0 | n | 86 | 16 | 17 |
F | 10.84 (10.46-11.23) | 14.93 (13.02-17.12) | 4.28 (3.83-4.79) | ||
R | 9.40 (8.02-11.03) | 17.15 (10.78-27.27) | 3.90 (2.54-6.00) | ||
1 | n | 62 | 15 | 14 | |
F | 7.80 (7.43-8.19) | 19.11 (15.33-23.83) | 3.25 (2.76-3.83) | ||
R | 7.28 (6.14-8.63) | 18.27 (12.55-26.60) | 3.46 (2.27-5.29) | ||
2+ | n | 47 | 10 | 13 | |
F | 8.49 (8.13-8.87) | 12.24 (11.04-13.57) | 5.58 (5.13-6.05) | ||
R | 8.54 (7.02-10.39) | 15.20 (9.40-24.58) | 5.68 (3.80-8.49) | ||
Between levels | PB | p < 0.1 | NS | NS |