Lung cancer type | Statisticb
| Ever smoking | Current smoking | Ever/current smoking |
---|
All lung cancerc
| n | 328 | 195 | 342 |
| F | 4.22 (4.16-4.28) | 9.29 (9.07-9.52) | 4.25 (4.20-4.31) |
| R | 5.50 (5.07-5.96) | 8.43 (7.63-9.31) | 5.48 (5.07-5.93) |
| H, PH
| 22.84, p < 0.001 | 13.76, p < 0.001 | 22.46, p < 0.001 |
Squamous cell carcinoma | n | 74 | 33 | 82 |
| F | 10.43 (9.72-11.20) | 12.74 (11.71-13.87) | 9.80 (9.18-10.47) |
| R | 11.56 (9.68-13.81) | 16.43 (12.66-21.32) | 11.62 (9.80-13.78) |
| H, PH
| 4.18, p < 0.001 | 5.70, p < 0.001 | 4.44, p < 0.001 |
Adenocarcinoma | n | 87 | 40 | 96 |
| F | 3.58 (3.39-3.78) | 4.40 (4.12-4.70) | 3.50 (3.33-3.67) |
| R | 2.99 (2.49-3.58) | 4.05 (3.15-5.22) | 3.10 (2.52-3.65) |
| H, PH
| 9.18, p < 0.001 | 12.28, p < 0.001 | 8.96, p < 0.001 |
Large cell carcinoma | n | 26 | 15 | 29 |
| F | 6.11 (4.78-7.81) | 8.41 (6.36-11.12) | 5.57 (4.48-6.92) |
| R | 5.59 (4.05-7.72) | 8.56 (5.29-13.86) | 5.33 (4.02-7.07) |
| H, PH
| 1.47, p < 0.1 | 2.13, p < 0.01 | 1.40, p < 0.1 |
Small cell carcinoma | n | 54 | 27 | 61 |
| F | 9.88 (8.94-10.02) | 15.31 (13.64-17.19) | 9.99 (9.09-10.97) |
| R | 10.98 (8.25-14.61) | 18.17 (12.92-25.56) | 11.14 (8.59-14.46) |
| H, PH
| 6.08, p < 0.001 | 5.67, p < 0.001 | 5.70, p < 0.001 |
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a Within each study, results for the relevant lung cancer type and smoking status are selected in the following preference order, within each sex, for:
- smoking product – any, cigarettes (ignoring other products), cigarettes only;
- cigarette type – any, manufactured (with or without handrolled), manufactured only;
- unexposed group – never any product, never cigarettes, other;
- follow-up period – longest available;
- race – all or nearest available, otherwise by race;
- overlapping studies – principal, subsidiary;
- age – whole study, widest available age group;
- Results are then selected for:
- sex – single sex results, combined sex results;
- adjustment for potential confounders – most available.
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b n = number of estimates combined, F = fixed-effect meta-analysis RR (95% CI), R = random-effects meta-analysis RR (95% CI), H = heterogeneity chisquared per degree of freedom, PH = probability value for heterogeneity expressed as p < 0.001, p < 0.05, p < 0.1 or NS (p ≥ 0.1), PB = probability value for between levels (see Methods) similarly expressed.
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c All or nearest available, must include at least squamous cell carcinoma and adenocarcinoma.