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Table 2 Total and stratified analysis of ABCG2 C421A polymorphism on cancer risk

From: The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature

Variables

AA versus CC

AC versus CC

A versus C

Recessive model

Dominant model

 

OR(95%CI)

P a

OR(95%CI)

P a

OR(95%CI)

P a

OR(95%CI)

P a

OR(95%CI)

P a

Total

1.021(0.730-1.428)

0.784

0.759(0.620-0.930) b

0.004

0.809(0.687-0.952) b

0.013

1.067(0.768-1.482)

0.935

0.771(0.634-0.938) b

0.005

Cancer type

colorectal cancer

1.073(0.491-2.344)

0.470

0.791(0.633-0.988)

0.445

0.840(0.688-1.025)

0.353

1.127(0.516-2.462)

0.494

0.806 (0.649-1.001)

0.388

lymphoma

1.200(0.736-1.958)

0.541

0.867(0.544-1.381) b

0.003

0.874(0.600-1.273) b

0.004

1.113 (0.692-1.791)

0.724

0.875(0.552-1.385) b

0.002

leukemia

1.371(0.507-3.704)

0.750

0.744(0.426-1.299) b

0.038

0.741(0.577-0.951)

0.072

1.474(0.543-4.002)

0.752

0.762(0.451-1.290) b

0.049

other

0.627(0.314-1.251)

0.419

0.574(0.407-0.808)

0.205

0.669(0.511-0.876)

0.827

0.822(0.420-1.607)

0.309

0.582 (0.420-0.807)

0.347

Source of control

Population based

0.684(0.383-1.223)

0.661

0.647(0.510-0.821)

0.289

0.710(0.582-0.867)

0.800

0.840(0.477-1.480)

0.594

0.654(0.520-0.823)

0.406

Hospital based

1.155(0.683-1.954)

0.897

0.721(0.627-0.829)

0.127

0.780(0.687-0.885)

0.158

1.225(0.724-2.075)

0.904

0.739(0.645-0.847)

0.133

HB + PB

-

   

-

 

-

 

-

 

Ethnicity

Asian

1.040(0.633-1.707)

0.143

0.856(0.287-2.549) b

0.000

0.923(0.478-1.784)b

0.002

1.069(0.666-1.715)

0.623

0.882(0.317-2.457) b

0.000

Caucasian

1.006(0.637-1.587)

0.846

0.723(0.638-0.820)

0.280

0.773( 0.690-0.866)

0.320

1.065(0.675-1.682)

0.849

0.737(0.652-0.833)

0.293

  1. aP value of Q-test for heterogeneity test.
  2. bRandom-effects model was used when P value for heterogeneity test <0.05; otherwise, fix-effects model was used.