Simultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer

BMC Cancer

Table 3 Common high-copy number changes (>10%)

Changes	Chr	Position (Mb)	Cytoband	Size (Mb)	Frequency	DGV^a	Korean CNV^b	Putative cancer-related genes
AMP9	1	150.82-150.93	1q21.3	0.11	9 (19%)	Y	Y	LCE3C, LCE3B, LCE3A, LCE2D, LCE2C, LCE2B
AMP64	8	120.51-135-87	8q24.22	15.37	9 (19%)	Y	Y	DDEF1, ENPP2, FAM83A, FAM84B, HAS2, MTSS1, MYC, NDRG1, RNF139, TG, WISP1
AMP67	8	144.37-145.55	8q24.3	1.18	5 (10%)	Y	Y	SCRIB, PLEC1, HSF1
AMP113	16	28.40-28.42	16p11.2	0.02	6 (13%)	Y	N	CLN3
AMP119	17	32.42-35.87	17q12	3.45	14 (29%)	Y	N	AATF, ACACA, CDC6, CSF3, ERBB2, FBXO47, GRB7, IGFBP4, LASP1, PCGF2, PERLD1, PLXDC1, PNMT, PPP1R1B, RARA, RPL19, RPL23, TBC1D3, THRA, TOP2A

^a Overlapping status with DGV (http://projects.tcag.ca/variation/) entries; ^b Overlapping status with CNVs identified from Koreans [35].
Y: overlap, N: no overlap, AMP: amplification, Chr: chromosome.

ISSN: 1471-2407