Figure 3

Examples of high-level copy number alterations. (A) Amplification on 8q24.22, where the MYC gene is located (red arrow). (B) Amplification on 17q12, where the ERBB2 gene is located (red arrow). (C) Homozygous deletion on 9p21, where CDKN2A and B are located (red arrow). The red and green spots in the plots on the right represent intensity ratios above 1.5 and below −1.5 on the log₂ scale, respectively. The X-axis represents individual chromosomes and the Y-axis represents signal intensity ratios (tumor/normal) on the log₂ scale.