SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer

Table 2 Correlation of Gene expression and segment copy number

The correlation between the top 500 differentially expressed genes and the segment copy numbers found within the coding regions was examined. For each up- or down-regulated gene the number of segments with an increase (amplification), a decrease (deletion) or no variation in copy number values were counted. Interestingly, a decrease in segmental copy number was neither found for up-regulated nor for down-regulated genes. Only 8 of 313 segments associated to 330 up-regulated genes show an increase in segmental copy number, whereas the remaining 98.48% of the segments show no significant change.

ISSN: 1471-2407