Figure 5

Impact of copy number alteration on gene expression for a region of chromosome 6. The impact of the copy number variation on the gene expression for a section of chromosome 6 (17.4 Mb to 18.6 Mb) is shown here. Six genes showing a significant up-regulation in gene expression are located within this region, including Met, Capza2, St7. The segmentation in the normal, the transgenic and the tumor samples are shown in subplots a, b and c, respectively. The gene positions are illustrated in (d) and in each plot, illustrating the copy number variation. One breakpoint was found within the Met gene resulting in a segment with more than a 3.5-fold amplification in CN.