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Table 2 Receiver operating characteristics curve (ROC) analysis using tissue and plasma miRNAs expression for discriminating endometrioid endometrial cancer (EEC) samples

From: Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma

miRNA/miRNA signature AUC [95% CI] p Sensitivity Specificity C +PV -PV
Tissues (EEC n = 73, NE  n= 31)
miR-99a 0.675 [0.572-0.767] 0.006 0.88 0.5 6.6 81.3 63.6
miR-100 0.652 [0.548-0.746] 0.03 0.86 0.5 6.5 80.8 58.3
miR-199b 0.706 [0.606-0.794] 0.001 0.81 0.71 5.3 87.5 60.6
miR-99a/miR-100/miR-199b 0.774 [0.678-0.853] <0.0001 0.61 0.89 0.76 93.3 48.1
Plasma (EEC n = 34, NE n = 14)
miR-99a 0.810 [0.669-0.909] <0.0001 0.76 0.79 1.23 89.3 57.9
miR-100 0.740 [0.592-0.857] 0.001 0.64 0.79 1.5 33.3 92.8
miR-199b 0.786 [0.642-0.892] 0.0002 0.79 0.71 2.48 86.7 58.8
miR-99a/miR-199b 0.903 [0.780-0.970] <0.0001 0.88 0.93 0.73 96.7 76.5
  1. AUC - area under curve; 95% CI – 95% confidence interval; C - factor; +PV - positive predictive value; -PV - negative predictive value.