Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma

Table 2 Receiver operating characteristics curve (ROC) analysis using tissue and plasma miRNAs expression for discriminating endometrioid endometrial cancer (EEC) samples

miRNA/miRNA signature	AUC [95% CI]	p	Sensitivity	Specificity	C	+PV	-PV
Tissues (EEC n = 73, NE n= 31)
miR-99a	0.675 [0.572-0.767]	0.006	0.88	0.5	6.6	81.3	63.6
miR-100	0.652 [0.548-0.746]	0.03	0.86	0.5	6.5	80.8	58.3
miR-199b	0.706 [0.606-0.794]	0.001	0.81	0.71	5.3	87.5	60.6
miR-99a/miR-100/miR-199b	0.774 [0.678-0.853]	<0.0001	0.61	0.89	0.76	93.3	48.1
Plasma (EEC n = 34, NE n = 14)
miR-99a	0.810 [0.669-0.909]	<0.0001	0.76	0.79	1.23	89.3	57.9
miR-100	0.740 [0.592-0.857]	0.001	0.64	0.79	1.5	33.3	92.8
miR-199b	0.786 [0.642-0.892]	0.0002	0.79	0.71	2.48	86.7	58.8
miR-99a/miR-199b	0.903 [0.780-0.970]	<0.0001	0.88	0.93	0.73	96.7	76.5

AUC - area under curve; 95% CI – 95% confidence interval; C - factor; +PV - positive predictive value; -PV - negative predictive value.