|
miRNA/miRNA signature
|
AUC [95% CI]
|
p
|
Sensitivity
|
Specificity
|
C
|
+PV
|
-PV
|
|---|
|
Tissues (EEC n = 73, NE n= 31)
|
|
miR-99a
|
0.675 [0.572-0.767]
|
0.006
|
0.88
|
0.5
|
6.6
|
81.3
|
63.6
|
|
miR-100
|
0.652 [0.548-0.746]
|
0.03
|
0.86
|
0.5
|
6.5
|
80.8
|
58.3
|
|
miR-199b
|
0.706 [0.606-0.794]
|
0.001
|
0.81
|
0.71
|
5.3
|
87.5
|
60.6
|
|
miR-99a/miR-100/miR-199b
|
0.774 [0.678-0.853]
|
<0.0001
|
0.61
|
0.89
|
0.76
|
93.3
|
48.1
|
|
Plasma (EEC n = 34, NE n = 14)
|
|
miR-99a
|
0.810 [0.669-0.909]
|
<0.0001
|
0.76
|
0.79
|
1.23
|
89.3
|
57.9
|
|
miR-100
|
0.740 [0.592-0.857]
|
0.001
|
0.64
|
0.79
|
1.5
|
33.3
|
92.8
|
|
miR-199b
|
0.786 [0.642-0.892]
|
0.0002
|
0.79
|
0.71
|
2.48
|
86.7
|
58.8
|
|
miR-99a/miR-199b
|
0.903 [0.780-0.970]
|
<0.0001
|
0.88
|
0.93
|
0.73
|
96.7
|
76.5
|
-
AUC - area under curve; 95% CI – 95% confidence interval; C - factor; +PV - positive predictive value; -PV - negative predictive value.
