Table 2 Characteristics of FN patients and comparison patients matched on basis of age (±5 years), tumor stage, chemotherapy regimen, and propensity score

Demographics

Age, mean±SD, y

63.3 ± 12.4

63.0 ±12.1

0.108

Male, %

49.0

50.7

0.674

Country of Residence

Australia

2.7

2.7

0.817

Austria

5.8

9.2

Belgium

11.6

11.9

France

24.5

18.4

Germany

10.2

12.2

Greece

2.7

1.7

Italy

5.1

7.8

Netherlands

8.8

8.5

Nordics

7.1

6.5

Portugal

1.4

1.7

Spain

12.6

12.6

Switzerland

2.7

2.4

UK and Ireland

4.8

4.4

NHL

Tumor Stage

I

14.6

14.6

---

II

16.7

16.7

III

19.4

19.4

IV

49.3

49.3

IPI/FLIPI Score

IPI Score

Low

16.4

20.8

0.368

Intermediate

50.4

50.6

High

19.6

17.3

Missing

13.6

11.4

FLIPI score

Low Risk

11.4

15.4

0.920

Intermediate Risk

36.4

23.1

Poor Risk

43.2

51.3

Missing

9.1

10.3

Bone Marrow Involvement

29.6

24.8

0.252

Clinical

Risk of FN, %

<20%

27.0

27.0

0.564

≥ 20%

73.0

73.0

Medical Conditions, %

Cardiovascular Disease

23.5

25.2

0.615

Respiratory Disease

7.8

4.8

0.128

Gastrointestinal Disease

6.1

5.1

0.564

Renal Disease

3.1

3.4

0.796

Hepatic/Biliary Disease

2.7

5.8

0.061

Haematologic/Lymphatic

5.1

3.1

0.221

Immunologic

5.4

3.7

0.317

Other

49.0

46.3

0.505

ECOG PS, %

0

47.6

52.4

0.182

1

31.0

31.6

2

10.2

7.5

3

5.1

3.7

4

1.0

0.7

Missing

5.1

4.1

Hematology

ANC (X10^{^}9L), mean±SD

5.4 ± 4.5

5.7 ± 3.4

0.794

Presence  of  Anemia Symptoms,  %

56.8

56.1

0.856

Treatment

Chemotherapy Regimen, %

CHOP-14

3.40

3.40

---

CHOP-14-R

27.89

27.89

CHOP-21

5.44

5.44

CHOP-21-R

63.27

63.27

Supportive Care, %

Index Cycle

G-CSF Prophylaxis

51.7

56.5

0.162

Anti-Infective FN Prophylaxis

13.3

11.6

0.529

Pre-Index Cycle

G-CSF

Prophylaxis

37.4

41.8

0.074

Treatment

9.5

6.5

0.128

Anti-Infective

FN Prophylaxis

7.8

5.8

0.303

FN Treatment

1.7

0.3

0.102

Transfusion

9.5

6.8

0.144

Index Cycle Number*

1

42.9

42.9

---

2

13.6

13.6

3

11.2

11.2

4

12.2

12.2

5

9.9

9.9

6

8.2

8.2

7

1.7

1.7

8

0.3

0.3

Total Number of Cycles (incl. index cycle thru end of course)

1

10.6

11.2

0.812

2

11.9

9.5

3

13.3

11.6

4

12.3

15.3

5

12.6

11.6

6

24.2

24.8

7

4.1

4.1

8

10.9

11.9