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Table 1 Patients, tumor characteristics and survival of mice inoculated with patient GBM cells

From: Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

Patient and GBM cells code

Gender

Age (years)

WHOaGlioma grade

Newly diagnosed/ recurrence

Tumor locationb

Hemisphere

Lobe

Ventricular involvement

Meningeal infiltration

Survival (days) of mice bearing secondary tumors

PT1

M

67

IV

new

cortical

right

temporal-occipital

No

No

55-65c

PT2

M

48

IV

new

cortico-undercortical

left

temporal-parietal-occipital

No

No

40-60c

PT3

M

53

IV

second recurrence

deep

left

parietal

Early subependymal involvement

Yes

80-90c

PT4

M

51

IV

new

undercortical

right

temporal-parietal

No

No

90-110c

PT5

F

70

IV

new

cortico-undercortical

right

frontal

No

No

90-110c

PT6

F

41

IV

new

cortico-undercortical

right

frontal-temporal

No

Yes

52-73

  1. These cells generated serially transplantable tumors in vivo. Survival mice data represent range of days required to induce large brain tumors and the sacrifice of the animals after injection of 105 GBM cells derived from explants of primary tumors (secondary tumors).
  2. aWorld Health Organization (WHO) criteria for brain tumor classification.
  3. bDetermined by Nuclear Magnetic resonance.
  4. cThese data for the corresponding patient GBM long-term cell cultures were published by Griffero and collaborators [15].