Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

BMC Cancer

Table 1 Patients, tumor characteristics and survival of mice inoculated with patient GBM cells

Patient and GBM cells code	Gender	Age (years)	WHO^aGlioma grade	Newly diagnosed/ recurrence	Tumor location^b	Hemisphere	Lobe	Ventricular involvement	Meningeal infiltration	Survival (days) of mice bearing secondary tumors
PT1	M	67	IV	new	cortical	right	temporal-occipital	No	No	55-65^c
PT2	M	48	IV	new	cortico-undercortical	left	temporal-parietal-occipital	No	No	40-60^c
PT3	M	53	IV	second recurrence	deep	left	parietal	Early subependymal involvement	Yes	80-90^c
PT4	M	51	IV	new	undercortical	right	temporal-parietal	No	No	90-110^c
PT5	F	70	IV	new	cortico-undercortical	right	frontal	No	No	90-110^c
PT6	F	41	IV	new	cortico-undercortical	right	frontal-temporal	No	Yes	52-73

These cells generated serially transplantable tumors in vivo. Survival mice data represent range of days required to induce large brain tumors and the sacrifice of the animals after injection of 10⁵ GBM cells derived from explants of primary tumors (secondary tumors).
^aWorld Health Organization (WHO) criteria for brain tumor classification.
^bDetermined by Nuclear Magnetic resonance.
^cThese data for the corresponding patient GBM long-term cell cultures were published by Griffero and collaborators [15].

ISSN: 1471-2407