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Table 1 Patients, tumor characteristics and survival of mice inoculated with patient GBM cells

From: Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

Patient and GBM cells code Gender Age (years) WHOaGlioma grade Newly diagnosed/ recurrence Tumor locationb Hemisphere Lobe Ventricular involvement Meningeal infiltration Survival (days) of mice bearing secondary tumors
PT1 M 67 IV new cortical right temporal-occipital No No 55-65c
PT2 M 48 IV new cortico-undercortical left temporal-parietal-occipital No No 40-60c
PT3 M 53 IV second recurrence deep left parietal Early subependymal involvement Yes 80-90c
PT4 M 51 IV new undercortical right temporal-parietal No No 90-110c
PT5 F 70 IV new cortico-undercortical right frontal No No 90-110c
PT6 F 41 IV new cortico-undercortical right frontal-temporal No Yes 52-73
  1. These cells generated serially transplantable tumors in vivo. Survival mice data represent range of days required to induce large brain tumors and the sacrifice of the animals after injection of 105 GBM cells derived from explants of primary tumors (secondary tumors).
  2. aWorld Health Organization (WHO) criteria for brain tumor classification.
  3. bDetermined by Nuclear Magnetic resonance.
  4. cThese data for the corresponding patient GBM long-term cell cultures were published by Griffero and collaborators [15].