Table 3 Gene-function analysis of all differentially expressed genes between PDAC xenograft SP and MP using DAVID
From: Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine
A. ENRICHED GENE CLUSTERS | ||
|---|---|---|
Gene group 1: Transcription Factors Enrichment Score: 1.78 | ||
1 | TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) |
2 | SNAI2 | snail homolog 2 (Drosophila) |
3 | CNOT4 | CCR4-NOT transcription complex, subunit 4 |
4 | ZBTB10 | zinc finger and BTB domain containing 10 |
5 | KLF12 | Kruppel-like factor 12 |
6 | ZFPM2 | zinc finger protein, multitype 2 |
7 | STAT4 | signal transducer and activator of transcription 4 |
8 | OSR2 | odd-skipped related 2 (Drosophila) |
9 | IKZF2 | IKAROS family zinc finger 2 (Helios) |
10 | PHF6 | PHD finger protein 6 |
11 | ZFHX4 | zinc finger homeobox 4 |
12 | SOX11 | SRY (sex determining region Y)-box 11 |
13 | CITED4 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 |
14 | ARNTL | aryl hydrocarbon receptor nuclear translocator-like |
15 | NFIB | nuclear factor I/B |
16 | GATA1 | GATA binding protein 1 (globin transcription factor 1) |
17 | ETS | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) |
18 | LEF1 | lymphoid enhancer-binding factor 1 |
Gene group 2: Adhesion Molecules Enrichment Score: 1.71 | ||
1 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 |
2 | MADCAM1 | mucosal vascular addressin cell adhesion molecule 1 |
3 | TREM2 | triggering receptor expressed on myeloid cells 2 |
4 | EFNB2 | ephrin-B2 |
5 | IGSF6 | immunoglobulin superfamily, member 6 |
6 | LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 |
7 | DSCAM | Down syndrome cell adhesion molecule |
8 | JAM2 | junctional adhesion molecule 2 |
9 | MDGA1 | MAM domain containing glycosylphosphatidylinositol anchor 1 |
Gene group 3: Homeobox Genes Enrichment Score: 1.51 | ||
1 | PKNOX2 | PBX/knotted 1 homeobox 2 |
2 | MEOX2 | mesenchyme homeobox 2 |
3 | SPIC | Spi-C transcription factor (Spi-1/PU.1 related) |
4 | IRX2 | iroquois homeobox 2 |
5 | EMX2 | empty spiracles homeobox 2 |
B. KEGG PATHWAYS | ||
Upregulated in SP | ||
| Â | Number of genes | genes |
Arrhythmogenic rightventricular cardiomyopathy | 4 | GJA1, ITGB3, LEF1, TCFL1 |
Pathways in cancer | 6 | TCF7L1, KITL, FASL, LEF1, FGF7, ETS1 |
Adherens junction | 3 | LEF1, SNAI2, TCF7L1 |
Downregulated in SP | ||
| Â | Number of genes | genes |
Lysosome | 3 | CTSA, CTSC, SLC11A1 |
Cell adhesion molecules (CAMs) | 3 | CADM1, HLA-DPB1, MADCAM1 |