Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

Table 6 Multivariate analysis for progression free survival (PFS) in Subgroup A and Subgroup B

PFS
	Parameter	SE	HR	95%CI	WAld’s p
Subgroup A(1st line, chemo-naïve)
Age	−0.028	0.011	0.973	0.952-0.994	0.012
TYMS
aberrant vs. normal	0.577	0.253	1.780	1.084-2.923	0.563
Treatment
platinum vs. taxanes	0.235	0.407	1.265	0.570-2.811	0.563
tax/plat vs. taxanes	−0.220	0.303	0.802	0.443-1.452	0.467
other vs. taxanes	0.088	0.376	1.092	0.522-2.282	0.816
aberrant TYMS *platinum	−1,687	0.564			0.003
aberrant TYMS *tax/plat	−1.200	0.433			0.006
Subgroup B(1st line, chemo-naïve)
Age	−0.002	0.010	0.978	0.959-0.998	0.034
TYMS
aberrant vs. normal	0.539	0.255	1.714	1.040-2.824	0.034
Treatment
platinum vs. taxanes	0.293	0.382	1.340	0.0633-2.836	0.444
tax/plat vs. taxanes	−0.129	0.285	0.879	0.502-1.537	0.650
other vs. taxanes	−6.631	0.439	0.532	0.225-1.258	0.151
aberrant TYMS*platinum	−1.719	0.551			0.002
aberrant TYMS*tax/plat	−1.233	0.420			0.003
aberrant TYMS *other treatment	−1.375	0.642			0.032

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