Progression free survival (months) | |||||||
---|---|---|---|---|---|---|---|
Total N | Events | Median | HR | 95% C.I. | Wald’s p | ||
Subgroup A | Aberrant TYMS | ||||||
No taxanes vs. Taxanes | 43 vs. 35 | 32 vs. 31 | 12.53 vs. 4.00 | 0.335 | 0.199-0.565 | <0.001 | |
No platinum vs. platinum | 66 vs. 13 | 53 vs. 10 | 6.72 vs. 16.92 | 2.247 | 1.097-4.602 | 0.027 | |
No tax/plat vs. tax/plat | 52 vs. 26 | 45 vs. 18 | 4.26 vs 15.64 | 1.982 | 1.143-3.437 | 0.015 | |
Normal TYMS | |||||||
No taxanes vs. Taxanes | 41 vs. 34 | 32 vs. 29 | 7.48 vs. 4.39 | 0.716 | 0.431-1.190 | 0.197 | |
No platinum vs. platinum | 66 vs. 9 | 53 vs. 8 | 6.89 vs. 5.97 | 0.844 | 0.400-1.779 | 0.656 | |
No tax/plat vs. tax/plat | 53 vs. 22 | 43 vs. 18 | 5.64 vs. 8.56 | 1.270 | 0.731-2.205 | 0.396 | |
Subgroup B | Aberrant TYMS | ||||||
No taxanes vs. Taxanes | 51 vs. 36 | 36 vs. 32 | 12.53 vs. 3.77 | 0.349 | 0.212-0.575 | <0.001 | |
No platinum vs. platinum | 73 vs. 14 | 58 vs. 10 | 6.72 vs. 16.92 | 2.216 | 1.088-4.512 | 0.028 | |
No tax/plat vs. tax/plat | 57 vs. 30 | 48 vs. 20 | 13.21 vs. 19.31 | 2.112 | 1.248-3.573 | 0.005 | |
Normal TYMS | |||||||
No taxanes vs. Taxanes | 47 vs. 39 | 36 vs. 33 | 6.89 vs. 5.93 | 0.771 | 0.479-1.242 | 0.286 | |
No platinum vs. platinum | 76 vs. 10 | 60 vs. 9 | 7.44 vs. 5.64 | 0.731 | 0.362-1.478 | 0.383 | |
No tax/plat vs. tax/plat | 62 vs. 24 | 49 vs. 20 | 12.18 vs. 12.85 | 1.049 | 0.623-1.767 | 0.857 |