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Table 5 TYMS mRNA expression was associated with patient progression free survival

From: Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

  

Progression free survival (months)

  

Total N

Events

Median

HR

95% C.I.

Wald’s p

Subgroup A

Aberrant TYMS

      
 

No taxanes vs. Taxanes

43 vs. 35

32 vs. 31

12.53 vs. 4.00

0.335

0.199-0.565

<0.001

 

No platinum vs. platinum

66 vs. 13

53 vs. 10

6.72 vs. 16.92

2.247

1.097-4.602

0.027

 

No tax/plat vs. tax/plat

52 vs. 26

45 vs. 18

4.26 vs 15.64

1.982

1.143-3.437

0.015

 

Normal TYMS

      
 

No taxanes vs. Taxanes

41 vs. 34

32 vs. 29

7.48 vs. 4.39

0.716

0.431-1.190

0.197

 

No platinum vs. platinum

66 vs. 9

53 vs. 8

6.89 vs. 5.97

0.844

0.400-1.779

0.656

 

No tax/plat vs. tax/plat

53 vs. 22

43 vs. 18

5.64 vs. 8.56

1.270

0.731-2.205

0.396

Subgroup B

Aberrant TYMS

      
 

No taxanes vs. Taxanes

51 vs. 36

36 vs. 32

12.53 vs. 3.77

0.349

0.212-0.575

<0.001

 

No platinum vs. platinum

73 vs. 14

58 vs. 10

6.72 vs. 16.92

2.216

1.088-4.512

0.028

 

No tax/plat vs. tax/plat

57 vs. 30

48 vs. 20

13.21 vs. 19.31

2.112

1.248-3.573

0.005

 

Normal TYMS

      
 

No taxanes vs. Taxanes

47 vs. 39

36 vs. 33

6.89 vs. 5.93

0.771

0.479-1.242

0.286

 

No platinum vs. platinum

76 vs. 10

60 vs. 9

7.44 vs. 5.64

0.731

0.362-1.478

0.383

 

No tax/plat vs. tax/plat

62 vs. 24

49 vs. 20

12.18 vs. 12.85

1.049

0.623-1.767

0.857